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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1
All Species:
43.03
Human Site:
T77
Identified Species:
78.89
UniProt:
P11586
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11586
NP_005947.3
935
101559
T77
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
Chimpanzee
Pan troglodytes
XP_001170520
978
105642
T133
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
Rhesus Macaque
Macaca mulatta
XP_001101889
921
99498
T77
I
K
L
P
R
T
T
T
E
S
E
V
I
K
Y
Dog
Lupus familis
XP_537476
935
101232
T77
I
K
L
P
K
T
A
T
E
S
E
V
L
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q922D8
935
101237
T77
I
K
L
P
R
T
S
T
E
S
E
V
L
K
Y
Rat
Rattus norvegicus
P27653
935
100977
T77
I
K
L
P
R
T
S
T
E
S
E
V
L
K
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034392
935
100213
T77
I
K
L
P
N
T
A
T
E
A
E
V
L
K
C
Frog
Xenopus laevis
NP_001080574
934
100531
T76
V
K
L
P
K
T
A
T
E
A
E
V
L
S
K
Zebra Danio
Brachydanio rerio
NP_955823
934
100443
T76
I
K
L
P
Q
T
A
T
E
T
E
V
L
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
T111
V
Q
L
P
R
S
I
T
E
V
E
L
L
D
K
Honey Bee
Apis mellifera
XP_623070
937
101449
T80
V
K
L
P
N
T
I
T
E
I
E
L
I
N
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
Baker's Yeast
Sacchar. cerevisiae
P07245
946
102187
T76
I
H
L
D
E
S
A
T
E
F
E
V
L
R
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
94.7
94.4
N.A.
92.8
93.3
N.A.
N.A.
80.7
82.3
76.9
N.A.
59.8
62.4
N.A.
N.A.
Protein Similarity:
100
93.4
96.6
97.7
N.A.
97.7
97.4
N.A.
N.A.
91.3
92.8
88.3
N.A.
74
77.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
86.6
86.6
N.A.
N.A.
66.6
53.3
60
N.A.
40
46.6
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
80
80
86.6
N.A.
73.3
66.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.8
58
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.6
72.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
39
0
0
16
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
8
0
0
0
93
0
93
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
70
0
0
0
0
0
16
0
0
8
0
0
16
0
0
% I
% Lys:
0
77
0
0
16
0
0
0
0
0
0
0
0
54
24
% K
% Leu:
0
0
93
0
0
0
0
0
0
0
0
16
62
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
0
% M
% Asn:
0
0
0
0
16
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
85
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
47
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
0
0
0
16
16
0
0
47
0
0
0
8
8
% S
% Thr:
0
0
0
0
0
77
24
93
0
8
0
0
0
0
0
% T
% Val:
24
0
0
0
0
0
0
0
0
8
0
77
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _