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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1
All Species:
21.82
Human Site:
T93
Identified Species:
40
UniProt:
P11586
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11586
NP_005947.3
935
101559
T93
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
Chimpanzee
Pan troglodytes
XP_001170520
978
105642
T149
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
Rhesus Macaque
Macaca mulatta
XP_001101889
921
99498
T93
T
S
L
N
E
D
S
T
I
H
G
F
L
V
Q
Dog
Lupus familis
XP_537476
935
101232
T93
T
S
L
N
E
D
L
T
V
H
G
F
I
V
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q922D8
935
101237
S93
I
S
L
N
E
D
A
S
V
H
G
F
I
V
Q
Rat
Rattus norvegicus
P27653
935
100977
T93
I
S
L
N
E
D
A
T
V
H
G
F
I
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034392
935
100213
A93
A
S
L
N
G
D
P
A
V
H
G
F
I
V
Q
Frog
Xenopus laevis
NP_001080574
934
100531
A92
M
S
I
N
E
D
P
A
Y
H
G
M
I
V
Q
Zebra Danio
Brachydanio rerio
NP_955823
934
100443
K92
T
E
V
N
E
N
S
K
I
H
G
L
I
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
R127
N
D
L
N
E
D
P
R
V
H
G
I
I
V
Q
Honey Bee
Apis mellifera
XP_623070
937
101449
N96
N
K
L
N
Q
D
P
N
I
H
G
I
I
V
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
Baker's Yeast
Sacchar. cerevisiae
P07245
946
102187
H92
D
Q
L
N
E
D
P
H
T
H
G
I
I
V
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
94.7
94.4
N.A.
92.8
93.3
N.A.
N.A.
80.7
82.3
76.9
N.A.
59.8
62.4
N.A.
N.A.
Protein Similarity:
100
93.4
96.6
97.7
N.A.
97.7
97.4
N.A.
N.A.
91.3
92.8
88.3
N.A.
74
77.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
73.3
80
N.A.
N.A.
66.6
53.3
53.3
N.A.
60
46.6
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
73.3
66.6
80
N.A.
66.6
66.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.8
58
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.6
72.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
16
16
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
0
85
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
77
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
54
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
93
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
93
0
0
0
0
0
% H
% Ile:
16
0
8
0
0
0
0
0
24
0
0
24
70
0
0
% I
% Lys:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
77
0
0
0
8
0
0
0
0
8
24
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
16
0
0
93
0
8
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
39
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
93
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
62
0
0
0
0
31
8
0
0
0
0
0
0
0
% S
% Thr:
39
0
0
0
0
0
0
39
8
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
54
0
0
0
0
93
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _