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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD1 All Species: 34.24
Human Site: Y816 Identified Species: 62.78
UniProt: P11586 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11586 NP_005947.3 935 101559 Y816 P S S F Q L L Y D L K L P V E
Chimpanzee Pan troglodytes XP_001170520 978 105642 Q863 Q A V Q R A A Q A P S S F Q L
Rhesus Macaque Macaca mulatta XP_001101889 921 99498 Q806 Q A V Q R A A Q A P S S F Q L
Dog Lupus familis XP_537476 935 101232 Y816 P S S F Q L L Y D L K L P V E
Cat Felis silvestris
Mouse Mus musculus Q922D8 935 101237 Y816 P S S F Q L L Y D L K L S I E
Rat Rattus norvegicus P27653 935 100977 Y816 P S S F Q L L Y D L K L S V E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034392 935 100213 Y816 P S N F R F L Y N V E L P V I
Frog Xenopus laevis NP_001080574 934 100531 Y815 P S N F K F L Y D V Q L P I A
Zebra Danio Brachydanio rerio NP_955823 934 100443 Y815 P N S F Q F L Y D V Q L P I A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96553 968 103485 Y849 G N Q F R L L Y D L E L P L V
Honey Bee Apis mellifera XP_623070 937 101449 Y818 N Y N F K V L Y D L N I N I E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPK5 634 67783 I522 L Y P L D I G I K D K I E A I
Baker's Yeast Sacchar. cerevisiae P07245 946 102187 Y828 P V D F H F L Y D V N S S V E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.6 94.7 94.4 N.A. 92.8 93.3 N.A. N.A. 80.7 82.3 76.9 N.A. 59.8 62.4 N.A. N.A.
Protein Similarity: 100 93.4 96.6 97.7 N.A. 97.7 97.4 N.A. N.A. 91.3 92.8 88.3 N.A. 74 77.1 N.A. N.A.
P-Site Identity: 100 0 0 100 N.A. 86.6 93.3 N.A. N.A. 53.3 53.3 60 N.A. 53.3 40 N.A. N.A.
P-Site Similarity: 100 13.3 13.3 100 N.A. 93.3 93.3 N.A. N.A. 86.6 86.6 86.6 N.A. 80 73.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 46.8 58 N.A.
Protein Similarity: N.A. N.A. N.A. 55.6 72.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 0 0 0 16 16 0 16 0 0 0 0 8 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 8 0 0 0 70 8 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 16 0 8 0 47 % E
% Phe: 0 0 0 77 0 31 0 0 0 0 0 0 16 0 0 % F
% Gly: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 8 0 0 0 16 0 31 16 % I
% Lys: 0 0 0 0 16 0 0 0 8 0 39 0 0 0 0 % K
% Leu: 8 0 0 8 0 39 77 0 0 47 0 62 0 8 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 16 24 0 0 0 0 0 8 0 16 0 8 0 0 % N
% Pro: 62 0 8 0 0 0 0 0 0 16 0 0 47 0 0 % P
% Gln: 16 0 8 16 39 0 0 16 0 0 16 0 0 16 0 % Q
% Arg: 0 0 0 0 31 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 47 39 0 0 0 0 0 0 0 16 24 24 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 8 16 0 0 8 0 0 0 31 0 0 0 39 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 16 0 0 0 0 0 77 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _