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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD1 All Species: 31.21
Human Site: Y852 Identified Species: 57.22
UniProt: P11586 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11586 NP_005947.3 935 101559 Y852 A Q H K A E V Y T K Q G F G N
Chimpanzee Pan troglodytes XP_001170520 978 105642 D893 A Q K I Y G A D D I E L L P E
Rhesus Macaque Macaca mulatta XP_001101889 921 99498 D836 A Q K I Y G A D D I E L L P E
Dog Lupus familis XP_537476 935 101232 Y852 A Q H K A E V Y T K Q G F G N
Cat Felis silvestris
Mouse Mus musculus Q922D8 935 101237 Y852 A Q N K A E I Y T K Q G F G N
Rat Rattus norvegicus P27653 935 100977 Y852 A Q N K A E I Y T K Q G F G N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034392 935 100213 Y852 A Q E K V A V Y T K Q G F G N
Frog Xenopus laevis NP_001080574 934 100531 Y851 A Q K K A D L Y T K Q G F G N
Zebra Danio Brachydanio rerio NP_955823 934 100443 Y851 A Q Q K V E R Y T K Q G F A D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96553 968 103485 L885 A E E K V K R L T D A G F G N
Honey Bee Apis mellifera XP_623070 937 101449 Y854 V Q K K I E K Y N K L G Y D T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPK5 634 67783 T552 E K Q I E M Y T Q Q G F S N L
Baker's Yeast Sacchar. cerevisiae P07245 946 102187 Y864 A Q R K I D M Y K E Q G F G N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.6 94.7 94.4 N.A. 92.8 93.3 N.A. N.A. 80.7 82.3 76.9 N.A. 59.8 62.4 N.A. N.A.
Protein Similarity: 100 93.4 96.6 97.7 N.A. 97.7 97.4 N.A. N.A. 91.3 92.8 88.3 N.A. 74 77.1 N.A. N.A.
P-Site Identity: 100 13.3 13.3 100 N.A. 86.6 86.6 N.A. N.A. 80 80 66.6 N.A. 46.6 40 N.A. N.A.
P-Site Similarity: 100 20 20 100 N.A. 100 100 N.A. N.A. 80 93.3 73.3 N.A. 60 46.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 46.8 58 N.A.
Protein Similarity: N.A. N.A. N.A. 55.6 72.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 60 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 85 0 0 0 39 8 16 0 0 0 8 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 16 0 16 16 8 0 0 0 8 8 % D
% Glu: 8 8 16 0 8 47 0 0 0 8 16 0 0 0 16 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 70 0 0 % F
% Gly: 0 0 0 0 0 16 0 0 0 0 8 77 0 62 0 % G
% His: 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 24 16 0 16 0 0 16 0 0 0 0 0 % I
% Lys: 0 8 31 77 0 8 8 0 8 62 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 8 8 0 0 8 16 16 0 8 % L
% Met: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 16 0 0 0 0 0 8 0 0 0 0 8 62 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % P
% Gln: 0 85 16 0 0 0 0 0 8 8 62 0 0 0 0 % Q
% Arg: 0 0 8 0 0 0 16 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 8 62 0 0 0 0 0 8 % T
% Val: 8 0 0 0 24 0 24 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 16 0 8 70 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _