KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK4
All Species:
24.85
Human Site:
S243
Identified Species:
49.7
UniProt:
P11802
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11802
NP_000066.1
303
33730
S243
D
D
W
P
R
D
V
S
L
P
R
G
A
F
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
S243
D
D
W
P
R
D
V
S
L
P
R
G
A
F
P
Dog
Lupus familis
XP_538252
303
33686
S243
D
D
W
P
R
D
V
S
L
P
R
G
A
F
S
Cat
Felis silvestris
Mouse
Mus musculus
P30285
303
33732
S243
D
D
W
P
R
E
V
S
L
P
R
G
A
F
A
Rat
Rattus norvegicus
P35426
303
33780
S243
D
D
W
P
R
E
V
S
L
P
R
G
A
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001007893
326
36832
A248
E
D
W
P
N
D
V
A
L
P
R
N
A
F
A
Frog
Xenopus laevis
Q91727
319
35666
T243
E
E
W
P
V
D
V
T
L
P
R
S
A
F
S
Zebra Danio
Brachydanio rerio
NP_001071245
297
33310
T240
P
A
E
D
Q
W
P
T
D
V
T
L
S
H
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_391955
457
50351
S400
G
E
W
P
E
N
V
S
L
S
W
T
A
F
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
A248
E
D
Q
W
P
D
V
A
L
P
W
S
S
F
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
P235
W
P
G
V
S
C
L
P
D
F
K
T
A
F
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
P235
W
R
G
V
T
S
L
P
D
Y
K
S
A
F
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
97
N.A.
94.7
95
N.A.
N.A.
65.3
72
71.9
N.A.
N.A.
35.2
N.A.
48.7
Protein Similarity:
100
N.A.
99.6
97.6
N.A.
97
97.3
N.A.
N.A.
75.7
79.9
80.1
N.A.
N.A.
50.3
N.A.
60.8
P-Site Identity:
100
N.A.
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
66.6
60
0
N.A.
N.A.
53.3
N.A.
40
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
80
80
20
N.A.
N.A.
66.6
N.A.
60
Percent
Protein Identity:
N.A.
43.8
N.A.
45.5
N.A.
N.A.
Protein Similarity:
N.A.
62.7
N.A.
64
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
17
0
0
0
0
84
0
17
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
42
59
0
9
0
50
0
0
25
0
0
0
0
0
0
% D
% Glu:
25
17
9
0
9
17
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
0
0
0
92
0
% F
% Gly:
9
0
17
0
0
0
0
0
0
0
0
42
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
17
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
17
0
75
0
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
9
0
0
0
0
0
9
0
0
0
% N
% Pro:
9
9
0
67
9
0
9
17
0
67
0
0
0
0
42
% P
% Gln:
0
0
9
0
9
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
0
42
0
0
0
0
0
59
0
0
0
9
% R
% Ser:
0
0
0
0
9
9
0
50
0
9
0
25
17
0
25
% S
% Thr:
0
0
0
0
9
0
0
17
0
0
9
17
0
0
0
% T
% Val:
0
0
0
17
9
0
75
0
0
9
0
0
0
0
0
% V
% Trp:
17
0
67
9
0
9
0
0
0
0
17
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _