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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SRF All Species: 25.45
Human Site: S176 Identified Species: 40
UniProt: P11831 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11831 NP_003122.1 508 51593 S176 M K K A Y E L S T L T G T Q V
Chimpanzee Pan troglodytes XP_518487 508 51590 S176 M K K A Y E L S T L T G T Q V
Rhesus Macaque Macaca mulatta XP_001093365 508 51688 S176 M K K A Y E L S T L T G T Q V
Dog Lupus familis XP_852302 508 51510 S176 M K K A Y E L S T L T G T Q V
Cat Felis silvestris
Mouse Mus musculus Q9JM73 504 51229 S172 M K K A Y E L S T L T G T Q V
Rat Rattus norvegicus NP_001102772 504 51157 S172 M K K A Y E L S T L T G T Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517936 150 15822
Chicken Gallus gallus Q90718 375 39146 S56 Q V L L L V A S E T G H V Y T
Frog Xenopus laevis P23790 448 46097 E129 G I M K K A Y E L S T L T G T
Zebra Danio Brachydanio rerio NP_001103996 539 55032 L164 L T G T Q V L L L V A S E T G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24535 449 47603 T129 H R S S G G L T L Q G L D N V
Honey Bee Apis mellifera XP_001120126 351 36852 Y31 S D A G S E M Y G R P S T S Q
Nematode Worm Caenorhab. elegans NP_492296 327 35027 A8 M T E A E D F A Q L L Q K L Q
Sea Urchin Strong. purpuratus XP_796790 410 43027 K91 K M E F I E N K L R R Y T T F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11746 286 32783
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.4 97.2 N.A. 96.4 96.6 N.A. 22.8 66.5 72.4 57.7 N.A. 35 33.4 28.7 33.8
Protein Similarity: 100 99.8 98.8 98 N.A. 97.4 97.6 N.A. 24 69.6 76.9 67.7 N.A. 48.8 40.3 41.1 45.6
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 6.6 13.3 6.6 N.A. 13.3 13.3 20 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 6.6 13.3 20 N.A. 33.3 20 40 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 33 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 47 0 7 7 7 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 7 0 0 0 0 0 0 7 0 0 % D
% Glu: 0 0 14 0 7 54 0 7 7 0 0 0 7 0 0 % E
% Phe: 0 0 0 7 0 0 7 0 0 0 0 0 0 0 7 % F
% Gly: 7 0 7 7 7 7 0 0 7 0 14 40 0 7 7 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % H
% Ile: 0 7 0 0 7 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 7 40 40 7 7 0 0 7 0 0 0 0 7 0 0 % K
% Leu: 7 0 7 7 7 0 54 7 27 47 7 14 0 7 0 % L
% Met: 47 7 7 0 0 0 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % P
% Gln: 7 0 0 0 7 0 0 0 7 7 0 7 0 40 14 % Q
% Arg: 0 7 0 0 0 0 0 0 0 14 7 0 0 0 0 % R
% Ser: 7 0 7 7 7 0 0 47 0 7 0 14 0 7 0 % S
% Thr: 0 14 0 7 0 0 0 7 40 7 47 0 60 14 14 % T
% Val: 0 7 0 0 0 14 0 0 0 7 0 0 7 0 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 40 0 7 7 0 0 0 7 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _