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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SRF All Species: 30.3
Human Site: S375 Identified Species: 47.62
UniProt: P11831 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11831 NP_003122.1 508 51593 S375 Q A S P S R D S S T D L T Q T
Chimpanzee Pan troglodytes XP_518487 508 51590 S375 Q A S P S R D S S T D L T Q T
Rhesus Macaque Macaca mulatta XP_001093365 508 51688 S375 Q G S P S R D S S T D L T Q T
Dog Lupus familis XP_852302 508 51510 S375 Q A S P S R D S S T D L T Q T
Cat Felis silvestris
Mouse Mus musculus Q9JM73 504 51229 S371 Q A S P S R D S S T D L T Q T
Rat Rattus norvegicus NP_001102772 504 51157 S371 Q A S P S R D S S T D L T Q T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517936 150 15822 D19 P S S D S S S D L T Q T S S S
Chicken Gallus gallus Q90718 375 39146 T244 S P S S D S S T D L T Q T S P
Frog Xenopus laevis P23790 448 46097 S317 A A Q A S P S S D S S S E L V
Zebra Danio Brachydanio rerio NP_001103996 539 55032 S408 P S P Q S S D S S P E I S Q T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24535 449 47603 S317 P A S K T E V S A P P A A S C
Honey Bee Apis mellifera XP_001120126 351 36852 D219 P A S G S S G D Q R M S A T G
Nematode Worm Caenorhab. elegans NP_492296 327 35027 N196 T F G E D D Y N N D E S G D D
Sea Urchin Strong. purpuratus XP_796790 410 43027 S279 G M L Q V Q P S H S Q L Q L Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11746 286 32783 A155 L N Q D Q V P A G A L K Q E V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.4 97.2 N.A. 96.4 96.6 N.A. 22.8 66.5 72.4 57.7 N.A. 35 33.4 28.7 33.8
Protein Similarity: 100 99.8 98.8 98 N.A. 97.4 97.6 N.A. 24 69.6 76.9 67.7 N.A. 48.8 40.3 41.1 45.6
P-Site Identity: 100 100 93.3 100 N.A. 100 100 N.A. 20 13.3 20 40 N.A. 20 20 0 13.3
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. 40 20 26.6 66.6 N.A. 33.3 20 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 33 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 54 0 7 0 0 0 7 7 7 0 7 14 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 0 0 0 14 14 7 47 14 14 7 40 0 0 7 7 % D
% Glu: 0 0 0 7 0 7 0 0 0 0 14 0 7 7 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 7 7 7 0 0 7 0 7 0 0 0 7 0 7 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % I
% Lys: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % K
% Leu: 7 0 7 0 0 0 0 0 7 7 7 47 0 14 0 % L
% Met: 0 7 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 7 7 0 0 0 0 0 0 % N
% Pro: 27 7 7 40 0 7 14 0 0 14 7 0 0 0 7 % P
% Gln: 40 0 14 14 7 7 0 0 7 0 14 7 14 47 7 % Q
% Arg: 0 0 0 0 0 40 0 0 0 7 0 0 0 0 0 % R
% Ser: 7 14 67 7 67 27 20 67 47 14 7 20 14 20 7 % S
% Thr: 7 0 0 0 7 0 0 7 0 47 7 7 47 7 47 % T
% Val: 0 0 0 0 7 7 7 0 0 0 0 0 0 0 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _