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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEFH
All Species:
15.45
Human Site:
S433
Identified Species:
37.78
UniProt:
P12036
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P12036
NP_066554.2
1026
112479
S433
L
P
K
I
P
S
V
S
T
H
I
K
V
K
S
Chimpanzee
Pan troglodytes
XP_515058
1018
111384
S433
L
P
K
I
P
S
V
S
T
H
I
K
V
K
S
Rhesus Macaque
Macaca mulatta
XP_001109476
915
99597
V358
E
Q
T
E
E
T
Q
V
T
E
E
V
T
E
E
Dog
Lupus familis
XP_543237
862
97231
S358
R
H
N
H
D
L
S
S
Y
Q
D
T
I
Q
Q
Cat
Felis silvestris
Mouse
Mus musculus
P19246
1090
116976
S431
L
P
K
I
P
S
I
S
T
H
I
K
V
K
S
Rat
Rattus norvegicus
P16884
1072
115359
S429
L
P
K
I
P
S
M
S
T
H
I
K
V
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517087
696
75544
G200
E
E
E
E
K
G
G
G
E
E
V
T
E
E
G
Chicken
Gallus gallus
P16053
858
95817
D356
N
D
L
T
T
Y
Q
D
T
I
H
Q
L
E
N
Frog
Xenopus laevis
NP_001081681
913
102801
T414
P
S
A
I
H
R
P
T
P
I
S
S
T
R
V
Zebra Danio
Brachydanio rerio
NP_001104684
849
95616
L349
L
Q
E
T
I
H
Q
L
E
N
E
L
K
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.6
81
38.2
N.A.
76.2
75.2
N.A.
38.4
40.4
35
39.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
97.7
83.6
53.1
N.A.
81.7
81.4
N.A.
46.2
54.1
52.5
54.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
6.6
N.A.
93.3
93.3
N.A.
0
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
20
20
N.A.
100
100
N.A.
20
33.3
20
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
10
0
0
10
0
0
10
0
0
0
0
% D
% Glu:
20
10
20
20
10
0
0
0
20
20
20
0
10
30
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
10
10
0
0
0
0
0
0
10
% G
% His:
0
10
0
10
10
10
0
0
0
40
10
0
0
0
0
% H
% Ile:
0
0
0
50
10
0
10
0
0
20
40
0
10
0
0
% I
% Lys:
0
0
40
0
10
0
0
0
0
0
0
40
10
40
0
% K
% Leu:
50
0
10
0
0
10
0
10
0
0
0
10
10
0
0
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
10
0
0
0
0
0
0
10
0
0
0
0
10
% N
% Pro:
10
40
0
0
40
0
10
0
10
0
0
0
0
0
0
% P
% Gln:
0
20
0
0
0
0
30
0
0
10
0
10
0
10
10
% Q
% Arg:
10
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% R
% Ser:
0
10
0
0
0
40
10
50
0
0
10
10
0
10
40
% S
% Thr:
0
0
10
20
10
10
0
10
60
0
0
20
20
0
10
% T
% Val:
0
0
0
0
0
0
20
10
0
0
10
10
40
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _