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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SKI All Species: 23.03
Human Site: S503 Identified Species: 56.3
UniProt: P12755 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P12755 NP_003027.1 728 80005 S503 L S S L S S P S F T S S S S A
Chimpanzee Pan troglodytes XP_001163333 684 77021 L539 E E V M R T Y L K Q Q E K L N
Rhesus Macaque Macaca mulatta XP_001086434 970 105418 S493 L S S L S S P S F T S S S S A
Dog Lupus familis XP_546730 790 86467 S562 L S S L S S P S L T S S S S A
Cat Felis silvestris
Mouse Mus musculus Q60698 725 80101 S500 L S S L S S P S F T S S S S A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517777 395 43609 V256 S V S A C V S V E F Q L V G S
Chicken Gallus gallus P49140 750 84264 S522 L S S L S S P S F T S S S S A
Frog Xenopus laevis Q02225 717 80721 S486 T S S L S S L S S P S F T S S
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120210 709 79498 S549 G V Y S A F P S Y E S G N N Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797484 647 73064 L495 R A G R E K L L H E L A R I R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.8 68.6 86.4 N.A. 92.1 N.A. N.A. 34 79.1 74.3 N.A. N.A. N.A. 32.1 N.A. 39.2
Protein Similarity: 100 55.2 70.6 87.4 N.A. 93.5 N.A. N.A. 40.5 86.6 82.2 N.A. N.A. N.A. 47.7 N.A. 54.5
P-Site Identity: 100 0 100 93.3 N.A. 100 N.A. N.A. 6.6 100 53.3 N.A. N.A. N.A. 20 N.A. 0
P-Site Similarity: 100 13.3 100 93.3 N.A. 100 N.A. N.A. 13.3 100 66.6 N.A. N.A. N.A. 46.6 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 10 10 0 0 0 0 0 0 10 0 0 50 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 10 0 0 10 0 0 0 10 20 0 10 0 0 0 % E
% Phe: 0 0 0 0 0 10 0 0 40 10 0 10 0 0 0 % F
% Gly: 10 0 10 0 0 0 0 0 0 0 0 10 0 10 0 % G
% His: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 0 0 10 0 0 10 0 0 0 10 0 0 % K
% Leu: 50 0 0 60 0 0 20 20 10 0 10 10 0 10 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 10 10 10 % N
% Pro: 0 0 0 0 0 0 60 0 0 10 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 20 0 0 0 10 % Q
% Arg: 10 0 0 10 10 0 0 0 0 0 0 0 10 0 10 % R
% Ser: 10 60 70 10 60 60 10 70 10 0 70 50 50 60 20 % S
% Thr: 10 0 0 0 0 10 0 0 0 50 0 0 10 0 0 % T
% Val: 0 20 10 0 0 10 0 10 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 10 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _