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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SKI All Species: 15.45
Human Site: S515 Identified Species: 37.78
UniProt: P12755 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P12755 NP_003027.1 728 80005 S515 S S A K D L G S P G A R A L P
Chimpanzee Pan troglodytes XP_001163333 684 77021 K551 K L N L I L Q K K Q Q L Q M E
Rhesus Macaque Macaca mulatta XP_001086434 970 105418 S505 S S A K D L G S P G A R A L P
Dog Lupus familis XP_546730 790 86467 S574 S S A K D L S S P G V H A P P
Cat Felis silvestris
Mouse Mus musculus Q60698 725 80101 S512 S S A K D L S S P G M H A P P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517777 395 43609 S268 V G S S T G V S L V V G Y S P
Chicken Gallus gallus P49140 750 84264 S534 S S A K D M S S P G M Q A P V
Frog Xenopus laevis Q02225 717 80721 E498 T S S S S A K E L S S P G M L
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120210 709 79498 H561 N N Q K E L P H K P K Q E I G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797484 647 73064 E507 R I R S S Q E E R L Q G A L A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.8 68.6 86.4 N.A. 92.1 N.A. N.A. 34 79.1 74.3 N.A. N.A. N.A. 32.1 N.A. 39.2
Protein Similarity: 100 55.2 70.6 87.4 N.A. 93.5 N.A. N.A. 40.5 86.6 82.2 N.A. N.A. N.A. 47.7 N.A. 54.5
P-Site Identity: 100 6.6 100 73.3 N.A. 73.3 N.A. N.A. 13.3 60 6.6 N.A. N.A. N.A. 13.3 N.A. 13.3
P-Site Similarity: 100 13.3 100 73.3 N.A. 73.3 N.A. N.A. 20 73.3 33.3 N.A. N.A. N.A. 46.6 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 50 0 0 10 0 0 0 0 20 0 60 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 10 0 10 20 0 0 0 0 10 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 0 0 10 20 0 0 50 0 20 10 0 10 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 20 0 0 0 % H
% Ile: 0 10 0 0 10 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 10 0 0 60 0 0 10 10 20 0 10 0 0 0 0 % K
% Leu: 0 10 0 10 0 60 0 0 20 10 0 10 0 30 10 % L
% Met: 0 0 0 0 0 10 0 0 0 0 20 0 0 20 0 % M
% Asn: 10 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 10 0 50 10 0 10 0 30 50 % P
% Gln: 0 0 10 0 0 10 10 0 0 10 20 20 10 0 0 % Q
% Arg: 10 0 10 0 0 0 0 0 10 0 0 20 0 0 0 % R
% Ser: 50 60 20 30 20 0 30 60 0 10 10 0 0 10 0 % S
% Thr: 10 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % T
% Val: 10 0 0 0 0 0 10 0 0 10 20 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _