KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEFA4
All Species:
4.55
Human Site:
S45
Identified Species:
25
UniProt:
P12838
Number Species:
4
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P12838
NP_001916.1
97
10504
S45
E
D
Q
D
I
S
I
S
F
A
W
D
K
S
S
Chimpanzee
Pan troglodytes
Q5G862
97
10486
S45
E
D
Q
D
I
S
I
S
F
A
W
D
K
S
S
Rhesus Macaque
Macaca mulatta
P60030
96
10526
N40
Q
E
Q
I
P
T
D
N
P
E
V
V
V
S
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P28311
92
10253
D39
E
E
Q
P
G
E
E
D
Q
A
V
S
I
S
F
Rat
Rattus norvegicus
Q62715
94
10283
Q40
E
Q
L
V
M
E
D
Q
D
I
S
I
S
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
44.3
N.A.
N.A.
45.3
45.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
58.7
N.A.
N.A.
61.8
54.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
13.3
N.A.
N.A.
26.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
40
N.A.
N.A.
33.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
60
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
40
0
40
0
0
40
20
20
0
0
40
0
0
0
% D
% Glu:
80
40
0
0
0
40
20
0
0
20
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
40
0
0
0
0
20
20
% F
% Gly:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
20
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
20
40
0
40
0
0
20
0
20
20
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
40
0
0
% K
% Leu:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
20
% L
% Met:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
20
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
20
20
0
0
0
20
0
0
0
0
0
0
% P
% Gln:
20
20
80
0
0
0
0
20
20
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
40
0
40
0
0
20
20
20
80
40
% S
% Thr:
0
0
0
0
0
20
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
20
0
0
0
0
0
0
40
20
20
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
40
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _