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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: XRCC6 All Species: 15.76
Human Site: S257 Identified Species: 24.76
UniProt: P12956 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.36
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P12956 NP_001460.1 609 69843 S257 E T R K R A L S R L K L K L N
Chimpanzee Pan troglodytes XP_521301 565 64749 K232 G I Y N L V Q K A L K P P P I
Rhesus Macaque Macaca mulatta XP_001105684 559 64235 K232 N L V Q K A L K P P P I K L Y
Dog Lupus familis XP_531714 608 69589 C255 E T R K R V L C R L K L K L S
Cat Felis silvestris
Mouse Mus musculus P23475 608 69466 S255 E T K K R V L S R L K F K L G
Rat Rattus norvegicus NP_620780 608 69468 S255 E T K K R V L S R L K F K L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507917 413 47433 T103 N E P V K T K T R T F N L D T
Chicken Gallus gallus O93257 632 72271 S279 E T R K R A L S R L N L Y L N
Frog Xenopus laevis NP_001082274 611 69251 S255 E A K K R A L S R L N L K L G
Zebra Danio Brachydanio rerio NP_956198 409 46098 V99 P R N S F K H V Y V Y H D L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q23976 631 72517 G258 D F L R R C L G H F S F Y L G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001189673 580 65781 G255 D H K K R T T G R I P F S L G
Poplar Tree Populus trichocarpa XP_002317447 628 70376 R267 M F T K R I V R R I T L S I A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_564012 621 70272 K268 V L A K R I A K R I T F V I C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SA95 645 72334 R268 N S K Q T P K R S Y F S N L P
Conservation
Percent
Protein Identity: 100 88 89.8 84.7 N.A. 83.2 83.2 N.A. 53.6 68 65.6 39 N.A. 25 N.A. N.A. 45.6
Protein Similarity: 100 89.3 91.1 92.9 N.A. 90.9 91.7 N.A. 59.9 81.9 81.1 53.2 N.A. 45.9 N.A. N.A. 64.8
P-Site Identity: 100 13.3 26.6 80 N.A. 73.3 73.3 N.A. 6.6 86.6 73.3 6.6 N.A. 20 N.A. N.A. 26.6
P-Site Similarity: 100 13.3 46.6 86.6 N.A. 80 80 N.A. 20 86.6 80 13.3 N.A. 33.3 N.A. N.A. 46.6
Percent
Protein Identity: 30.7 N.A. N.A. 30.2 N.A. 27.6
Protein Similarity: 50 N.A. N.A. 48.6 N.A. 48.5
P-Site Identity: 26.6 N.A. N.A. 20 N.A. 6.6
P-Site Similarity: 46.6 N.A. N.A. 33.3 N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 0 27 7 0 7 0 0 0 0 0 7 % A
% Cys: 0 0 0 0 0 7 0 7 0 0 0 0 0 0 7 % C
% Asp: 14 0 0 0 0 0 0 0 0 0 0 0 7 7 0 % D
% Glu: 40 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % E
% Phe: 0 14 0 0 7 0 0 0 0 7 14 34 0 0 0 % F
% Gly: 7 0 0 0 0 0 0 14 0 0 0 0 0 0 34 % G
% His: 0 7 0 0 0 0 7 0 7 0 0 7 0 0 0 % H
% Ile: 0 7 0 0 0 14 0 0 0 20 0 7 0 14 7 % I
% Lys: 0 0 34 60 14 7 14 20 0 0 34 0 40 0 0 % K
% Leu: 0 14 7 0 7 0 54 0 0 47 0 34 7 74 0 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 20 0 7 7 0 0 0 0 0 0 14 7 7 0 14 % N
% Pro: 7 0 7 0 0 7 0 0 7 7 14 7 7 7 7 % P
% Gln: 0 0 0 14 0 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 0 7 20 7 67 0 0 14 67 0 0 0 0 0 0 % R
% Ser: 0 7 0 7 0 0 0 34 7 0 7 7 14 0 7 % S
% Thr: 0 34 7 0 7 14 7 7 0 7 14 0 0 0 7 % T
% Val: 7 0 7 7 0 27 7 7 0 7 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 0 0 0 7 7 7 0 14 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _