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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LYL1 All Species: 9.7
Human Site: S249 Identified Species: 19.39
UniProt: P12980 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P12980 NP_005574.2 280 29938 S249 R A E A A A R S Q P A P P A D
Chimpanzee Pan troglodytes Q8MI03 201 20743 S171 L Q S D E L D S K M A S Y V A
Rhesus Macaque Macaca mulatta XP_001110523 737 77582 G637 G P Q G G A P G E T R D R S S
Dog Lupus familis XP_853573 183 18958 Q153 A E A A E R S Q F A P P A G P
Cat Felis silvestris
Mouse Mus musculus P27792 278 30123 S247 H R V E A A R S Q P V L P G D
Rat Rattus norvegicus Q66HH3 278 29939 S247 H R V E A A R S Q P V L P G D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510416 353 37704 K287 R D R T A V G K E P R P L H C
Chicken Gallus gallus P24899 311 33749 S279 S S L D G A A S P D S F T E E
Frog Xenopus laevis O73823 394 43024 S362 S S L D G A P S P D S Y S E E
Zebra Danio Brachydanio rerio O93507 324 35687 S290 S L L D G D A S P E S F T E D
Tiger Blowfish Takifugu rubipres Q90YI8 371 40876 P311 D I M E T M S P G S S C G S L
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792477 400 43713 G355 S S S E S G I G D S E S I C G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 24.2 33.3 55.3 N.A. 77.8 80 N.A. 49.5 34.7 29.1 33.6 32.8 N.A. N.A. N.A. 27.2
Protein Similarity: 100 33.2 34.5 60 N.A. 83.5 84.2 N.A. 56.3 44 38.8 46.2 42.5 N.A. N.A. N.A. 39.7
P-Site Identity: 100 13.3 6.6 13.3 N.A. 53.3 53.3 N.A. 26.6 13.3 13.3 13.3 0 N.A. N.A. N.A. 0
P-Site Similarity: 100 20 26.6 13.3 N.A. 53.3 53.3 N.A. 33.3 33.3 33.3 20 13.3 N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 9 17 34 50 17 0 0 9 17 0 9 9 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 9 9 % C
% Asp: 9 9 0 34 0 9 9 0 9 17 0 9 0 0 34 % D
% Glu: 0 9 9 34 17 0 0 0 17 9 9 0 0 25 17 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 17 0 0 0 % F
% Gly: 9 0 0 9 34 9 9 17 9 0 0 0 9 25 9 % G
% His: 17 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 9 0 0 0 0 9 0 0 0 0 0 9 0 0 % I
% Lys: 0 0 0 0 0 0 0 9 9 0 0 0 0 0 0 % K
% Leu: 9 9 25 0 0 9 0 0 0 0 0 17 9 0 9 % L
% Met: 0 0 9 0 0 9 0 0 0 9 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 9 0 0 0 0 17 9 25 34 9 25 25 0 9 % P
% Gln: 0 9 9 0 0 0 0 9 25 0 0 0 0 0 0 % Q
% Arg: 17 17 9 0 0 9 25 0 0 0 17 0 9 0 0 % R
% Ser: 34 25 17 0 9 0 17 59 0 17 34 17 9 17 9 % S
% Thr: 0 0 0 9 9 0 0 0 0 9 0 0 17 0 0 % T
% Val: 0 0 17 0 0 9 0 0 0 0 17 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 9 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _