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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CFTR
All Species:
36.97
Human Site:
S549
Identified Species:
73.94
UniProt:
P13569
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13569
NP_000483.3
1480
168142
S549
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
Chimpanzee
Pan troglodytes
Q2QLE5
1480
168220
S549
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
Rhesus Macaque
Macaca mulatta
NP_001028110
1481
168436
S549
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
Dog
Lupus familis
XP_542642
1516
170242
N535
T
T
Y
V
L
L
G
N
V
I
T
A
S
R
V
Cat
Felis silvestris
Mouse
Mus musculus
P26361
1476
167852
S549
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
Rat
Rattus norvegicus
P34158
1476
167812
S549
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Q07DZ6
1484
168832
S549
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
Chicken
Gallus gallus
Q5F364
1525
170953
Y517
G
I
K
V
L
K
L
Y
A
W
E
L
A
F
R
Frog
Xenopus laevis
P26363
1485
168877
S550
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
Zebra Danio
Brachydanio rerio
NP_001038348
1485
168381
S548
A
E
G
G
L
N
L
S
G
G
Q
K
A
R
V
Tiger Blowfish
Takifugu rubipres
NP_001041505
1511
170002
S548
M
E
G
G
V
T
L
S
G
G
Q
R
A
R
L
Fruit Fly
Dros. melanogaster
P91660
1290
143990
N406
P
G
N
P
P
S
N
N
N
E
A
D
L
L
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.1
23.6
N.A.
78.5
78
N.A.
83.3
20.6
77.3
55.7
58.7
28.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
98.9
44.2
N.A.
88.7
88.1
N.A.
92.3
41.3
88.3
75.5
76.4
50.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
100
20
100
66.6
80
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
33.3
N.A.
100
100
N.A.
100
33.3
100
86.6
93.3
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
9
0
9
9
84
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% D
% Glu:
0
75
0
0
0
0
0
0
0
9
9
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
67
9
75
75
0
0
9
0
75
75
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
42
0
0
0
0
9
0
0
0
0
59
% I
% Lys:
0
0
9
0
0
9
0
0
0
0
0
9
0
0
9
% K
% Leu:
0
0
0
0
25
9
84
0
0
0
0
9
9
9
9
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
9
9
17
9
0
0
0
0
0
0
% N
% Pro:
9
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
75
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
67
0
84
9
% R
% Ser:
0
0
0
0
0
9
0
75
0
0
0
0
9
0
0
% S
% Thr:
9
9
0
0
0
67
0
0
0
0
9
0
0
0
0
% T
% Val:
0
0
0
17
25
0
0
0
9
0
0
0
0
0
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _