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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDIA4 All Species: 18.79
Human Site: S224 Identified Species: 29.52
UniProt: P13667 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P13667 NP_004902.1 645 72932 S224 E K A A K E L S K R S P P I P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539831 628 70318 K215 K L A P E Y E K A A K E L S K
Cat Felis silvestris
Mouse Mus musculus P08003 638 71955 S217 E K A A K E L S K R S P P I P
Rat Rattus norvegicus P38659 643 72702 S222 E K A A K E L S K R S P P I P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q8JG64 505 56163 K102 V S G Y P T L K I F R D G E E
Frog Xenopus laevis NP_001088331 637 71736 S217 E K A A Q E L S K R S P P I P
Zebra Danio Brachydanio rerio NP_956073 645 72696 S224 E K A A K E L S N R T P P I P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54399 496 55763 L93 D A T V E G E L A E Q Y A V R
Honey Bee Apis mellifera XP_623282 490 55838 D87 D C T E S G K D T C N K Y S V
Nematode Worm Caenorhab. elegans P34329 618 69779 K194 E K A A Q K L K A Q G S K V K
Sea Urchin Strong. purpuratus XP_791396 637 72173 K213 E T A A T A L K S N D P P V L
Poplar Tree Populus trichocarpa
Maize Zea mays P52588 513 57078 Q109 L A T K Y E I Q G F P T I K I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SRG3 508 56346 G105 A N E Y K I Q G F P T L K I L
Baker's Yeast Sacchar. cerevisiae P17967 522 58209 S119 K N S D V N N S I D Y E G P R
Red Bread Mold Neurospora crassa Q92249 369 39263
Conservation
Percent
Protein Identity: 100 N.A. N.A. 81.7 N.A. 87.7 88 N.A. N.A. 32.8 72 72.2 N.A. 30.2 30.8 47.4 53.1
Protein Similarity: 100 N.A. N.A. 89.1 N.A. 93.6 94.2 N.A. N.A. 47.4 84.6 84.8 N.A. 47.5 47.4 63 68.9
P-Site Identity: 100 N.A. N.A. 6.6 N.A. 100 100 N.A. N.A. 6.6 93.3 86.6 N.A. 0 0 33.3 40
P-Site Similarity: 100 N.A. N.A. 20 N.A. 100 100 N.A. N.A. 6.6 100 93.3 N.A. 20 13.3 60 46.6
Percent
Protein Identity: N.A. 29.6 N.A. 30.3 23.5 22.3
Protein Similarity: N.A. 44.5 N.A. 48.5 37.5 34.8
P-Site Identity: N.A. 6.6 N.A. 13.3 6.6 0
P-Site Similarity: N.A. 13.3 N.A. 20 20 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 14 54 47 0 7 0 0 20 7 0 0 7 0 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 14 0 0 7 0 0 0 7 0 7 7 7 0 0 0 % D
% Glu: 47 0 7 7 14 40 14 0 0 7 0 14 0 7 7 % E
% Phe: 0 0 0 0 0 0 0 0 7 14 0 0 0 0 0 % F
% Gly: 0 0 7 0 0 14 0 7 7 0 7 0 14 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 7 0 14 0 0 0 7 40 7 % I
% Lys: 14 40 0 7 34 7 7 27 27 0 7 7 14 7 14 % K
% Leu: 7 7 0 0 0 0 54 7 0 0 0 7 7 0 14 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 14 0 0 0 7 7 0 7 7 7 0 0 0 0 % N
% Pro: 0 0 0 7 7 0 0 0 0 7 7 40 40 7 34 % P
% Gln: 0 0 0 0 14 0 7 7 0 7 7 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 34 7 0 0 0 14 % R
% Ser: 0 7 7 0 7 0 0 40 7 0 27 7 0 14 0 % S
% Thr: 0 7 20 0 7 7 0 0 7 0 14 7 0 0 0 % T
% Val: 7 0 0 7 7 0 0 0 0 0 0 0 0 20 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 14 7 7 0 0 0 0 7 7 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _