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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR2A
All Species:
43.64
Human Site:
S268
Identified Species:
64
UniProt:
P13861
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13861
NP_004148.1
404
45518
S268
L
L
K
S
L
E
V
S
E
R
M
K
I
V
D
Chimpanzee
Pan troglodytes
XP_001148361
477
52826
S342
F
L
K
S
L
E
F
S
E
R
L
K
V
V
D
Rhesus Macaque
Macaca mulatta
XP_001089109
461
51060
S326
F
L
K
S
L
E
F
S
E
R
L
K
V
V
D
Dog
Lupus familis
XP_541890
401
45078
S265
L
L
K
S
L
E
M
S
E
R
M
K
I
V
D
Cat
Felis silvestris
Mouse
Mus musculus
P12367
401
45371
S265
L
F
K
S
L
E
M
S
E
R
M
K
I
V
D
Rat
Rattus norvegicus
P12368
401
45522
S265
L
F
K
S
L
E
M
S
E
R
M
K
I
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509189
323
36258
I208
I
Y
K
D
G
E
Q
I
I
A
Q
G
D
L
A
Chicken
Gallus gallus
Q5ZM91
382
43332
W263
I
L
E
S
L
D
K
W
E
R
L
T
V
A
D
Frog
Xenopus laevis
NP_001084637
402
45172
S267
F
L
K
S
L
E
F
S
E
R
L
K
V
V
D
Zebra Danio
Brachydanio rerio
NP_001070838
397
44672
S265
L
L
K
S
L
E
L
S
E
R
M
K
I
V
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P81900
377
42730
Y249
M
L
K
A
L
Q
N
Y
E
R
M
N
L
A
D
Honey Bee
Apis mellifera
XP_392905
383
43849
Y255
M
L
K
S
L
E
P
Y
E
R
M
N
L
A
D
Nematode Worm
Caenorhab. elegans
P30625
366
41449
W247
I
L
A
D
L
D
Q
W
E
R
A
N
V
A
D
Sea Urchin
Strong. purpuratus
Q26619
369
41770
Y246
I
F
K
S
L
E
P
Y
E
R
M
N
L
A
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
S285
F
R
K
I
L
L
G
S
S
F
K
K
R
L
M
Red Bread Mold
Neurospora crassa
Q01386
385
42138
Y268
I
L
K
T
L
T
P
Y
E
R
S
K
I
A
D
Conservation
Percent
Protein Identity:
100
58.4
61.1
91
N.A.
86.8
86.8
N.A.
58.6
35.1
64.8
71.2
N.A.
48.7
49.7
32.9
52.2
Protein Similarity:
100
68.3
70.7
94.5
N.A.
91.3
92
N.A.
69
52.7
80.6
83.6
N.A.
67.8
69
54.9
69
P-Site Identity:
100
73.3
73.3
93.3
N.A.
86.6
86.6
N.A.
13.3
40
73.3
93.3
N.A.
46.6
60
33.3
53.3
P-Site Similarity:
100
86.6
86.6
100
N.A.
93.3
93.3
N.A.
26.6
73.3
86.6
100
N.A.
73.3
73.3
53.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
37.2
35.4
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
55.2
51.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
0
0
0
0
0
7
7
0
0
38
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
13
0
13
0
0
0
0
0
0
7
0
88
% D
% Glu:
0
0
7
0
0
69
0
0
88
0
0
0
0
0
0
% E
% Phe:
25
19
0
0
0
0
19
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
7
0
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
32
0
0
7
0
0
0
7
7
0
0
0
38
0
0
% I
% Lys:
0
0
88
0
0
0
7
0
0
0
7
63
0
0
0
% K
% Leu:
32
69
0
0
94
7
7
0
0
0
25
0
19
13
0
% L
% Met:
13
0
0
0
0
0
19
0
0
0
50
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
0
25
0
0
0
% N
% Pro:
0
0
0
0
0
0
19
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
13
0
0
0
7
0
0
0
0
% Q
% Arg:
0
7
0
0
0
0
0
0
0
88
0
0
7
0
0
% R
% Ser:
0
0
0
69
0
0
0
57
7
0
7
0
0
0
0
% S
% Thr:
0
0
0
7
0
7
0
0
0
0
0
7
0
0
0
% T
% Val:
0
0
0
0
0
0
7
0
0
0
0
0
32
50
0
% V
% Trp:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
25
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _