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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR2A
All Species:
10.91
Human Site:
T290
Identified Species:
16
UniProt:
P13861
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13861
NP_004148.1
404
45518
T290
K
D
G
E
R
I
I
T
Q
G
E
K
A
D
S
Chimpanzee
Pan troglodytes
XP_001148361
477
52826
A364
N
D
G
E
Q
I
I
A
Q
G
D
S
A
D
S
Rhesus Macaque
Macaca mulatta
XP_001089109
461
51060
A348
N
D
G
E
Q
I
I
A
Q
G
D
S
A
D
S
Dog
Lupus familis
XP_541890
401
45078
T287
K
D
G
E
R
I
I
T
Q
G
E
K
A
D
S
Cat
Felis silvestris
Mouse
Mus musculus
P12367
401
45371
A287
K
D
G
E
R
I
I
A
Q
G
E
K
A
D
S
Rat
Rattus norvegicus
P12368
401
45522
T287
K
D
G
E
R
I
I
T
Q
G
E
K
A
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509189
323
36258
M230
S
G
E
V
K
I
T
M
K
R
K
N
K
Q
E
Chicken
Gallus gallus
Q5ZM91
382
43332
V285
E
D
G
Q
K
I
V
V
Q
G
E
P
G
D
E
Frog
Xenopus laevis
NP_001084637
402
45172
A289
C
D
E
E
Q
I
I
A
Q
G
D
G
A
D
S
Zebra Danio
Brachydanio rerio
NP_001070838
397
44672
M287
Q
D
G
E
R
I
I
M
Q
G
D
K
A
D
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P81900
377
42730
K271
D
N
G
E
R
I
I
K
Q
G
D
A
A
D
G
Honey Bee
Apis mellifera
XP_392905
383
43849
K277
S
D
G
D
Q
I
I
K
Q
G
D
S
A
D
G
Nematode Worm
Caenorhab. elegans
P30625
366
41449
E269
E
P
G
T
H
V
V
E
Q
G
Q
P
G
D
E
Sea Urchin
Strong. purpuratus
Q26619
369
41770
A268
E
D
G
D
C
I
I
A
Q
G
D
G
A
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
T307
M
P
V
L
K
S
L
T
T
Y
D
R
A
K
L
Red Bread Mold
Neurospora crassa
Q01386
385
42138
L290
P
A
G
H
E
I
I
L
E
G
D
P
G
H
S
Conservation
Percent
Protein Identity:
100
58.4
61.1
91
N.A.
86.8
86.8
N.A.
58.6
35.1
64.8
71.2
N.A.
48.7
49.7
32.9
52.2
Protein Similarity:
100
68.3
70.7
94.5
N.A.
91.3
92
N.A.
69
52.7
80.6
83.6
N.A.
67.8
69
54.9
69
P-Site Identity:
100
66.6
66.6
100
N.A.
93.3
100
N.A.
6.6
46.6
60
73.3
N.A.
60
53.3
26.6
53.3
P-Site Similarity:
100
80
80
100
N.A.
93.3
100
N.A.
26.6
73.3
73.3
86.6
N.A.
73.3
73.3
53.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
37.2
35.4
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
55.2
51.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
33.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
32
0
0
0
7
75
0
0
% A
% Cys:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
7
69
0
13
0
0
0
0
0
0
57
0
0
82
0
% D
% Glu:
19
0
13
57
7
0
0
7
7
0
32
0
0
0
19
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
82
0
0
0
0
0
0
88
0
13
19
0
19
% G
% His:
0
0
0
7
7
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
0
0
0
88
75
0
0
0
0
0
0
0
0
% I
% Lys:
25
0
0
0
19
0
0
13
7
0
7
32
7
7
0
% K
% Leu:
0
0
0
7
0
0
7
7
0
0
0
0
0
0
7
% L
% Met:
7
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% M
% Asn:
13
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
7
13
0
0
0
0
0
0
0
0
0
19
0
0
0
% P
% Gln:
7
0
0
7
25
0
0
0
82
0
7
0
0
7
0
% Q
% Arg:
0
0
0
0
38
0
0
0
0
7
0
7
0
0
0
% R
% Ser:
13
0
0
0
0
7
0
0
0
0
0
19
0
0
50
% S
% Thr:
0
0
0
7
0
0
7
25
7
0
0
0
0
0
0
% T
% Val:
0
0
7
7
0
7
13
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _