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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD2
All Species:
13.94
Human Site:
S342
Identified Species:
30.67
UniProt:
P13995
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13995
NP_006627.2
350
37895
S342
E
E
R
E
V
L
K
S
K
E
L
G
V
A
T
Chimpanzee
Pan troglodytes
XP_515555
350
37849
S342
E
E
R
E
V
L
K
S
K
E
L
G
V
A
T
Rhesus Macaque
Macaca mulatta
XP_001091218
502
54417
L495
M
L
L
K
N
T
L
L
A
A
K
Q
I
I
Y
Dog
Lupus familis
XP_540223
398
43317
P390
E
E
R
E
V
V
K
P
K
E
R
G
V
A
S
Cat
Felis silvestris
Mouse
Mus musculus
P18155
350
37844
S342
E
E
L
E
V
F
K
S
K
Q
R
G
V
A
T
Rat
Rattus norvegicus
NP_001102868
349
37698
S341
E
E
L
E
V
L
K
S
T
Q
R
G
V
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZKA5
337
36393
P329
A
A
K
K
L
L
K
P
K
A
L
E
A
L
T
Frog
Xenopus laevis
NP_001086806
335
36223
T328
A
K
K
M
L
K
P
T
E
L
Q
A
L
A
M
Zebra Danio
Brachydanio rerio
NP_001002181
338
36917
P329
K
N
M
I
L
T
P
P
Q
R
V
R
M
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q04448
309
33532
Q302
T
L
K
A
A
R
K
Q
F
D
D
R
K
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793717
336
36041
A329
K
R
N
I
Q
R
Q
A
Q
A
A
S
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
47.4
77.8
N.A.
92
90.5
N.A.
N.A.
81.4
79.7
73.7
N.A.
50
N.A.
N.A.
55.1
Protein Similarity:
100
99.7
57.5
82.1
N.A.
96
94.5
N.A.
N.A.
88
88.5
86
N.A.
64.5
N.A.
N.A.
73.4
P-Site Identity:
100
100
0
73.3
N.A.
73.3
73.3
N.A.
N.A.
33.3
6.6
6.6
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
13.3
86.6
N.A.
80
80
N.A.
N.A.
53.3
46.6
40
N.A.
33.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
10
0
10
10
0
0
10
10
28
10
10
10
64
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
0
% D
% Glu:
46
46
0
46
0
0
0
0
10
28
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
46
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
19
0
0
0
0
0
0
0
0
10
10
0
% I
% Lys:
19
10
28
19
0
10
64
0
46
0
10
0
10
0
0
% K
% Leu:
0
19
28
0
28
37
10
10
0
10
28
0
10
10
0
% L
% Met:
10
0
10
10
0
0
0
0
0
0
0
0
10
0
10
% M
% Asn:
0
10
10
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
19
28
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
10
10
19
19
10
10
0
0
0
% Q
% Arg:
0
10
28
0
0
19
0
0
0
10
28
19
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
37
0
0
0
10
10
19
28
% S
% Thr:
10
0
0
0
0
19
0
10
10
0
0
0
0
0
46
% T
% Val:
0
0
0
0
46
10
0
0
0
0
10
0
46
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _