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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD2
All Species:
18.18
Human Site:
S63
Identified Species:
40
UniProt:
P13995
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13995
NP_006627.2
350
37895
S63
E
V
E
E
W
V
A
S
G
N
K
R
P
H
L
Chimpanzee
Pan troglodytes
XP_515555
350
37849
S63
E
V
E
E
W
V
A
S
G
N
K
R
P
H
L
Rhesus Macaque
Macaca mulatta
XP_001091218
502
54417
L232
G
V
E
S
W
V
S
L
G
N
R
R
P
H
L
Dog
Lupus familis
XP_540223
398
43317
S111
E
V
E
E
W
V
A
S
G
N
K
R
P
H
L
Cat
Felis silvestris
Mouse
Mus musculus
P18155
350
37844
S63
E
V
E
E
W
V
A
S
G
N
K
R
P
H
L
Rat
Rattus norvegicus
NP_001102868
349
37698
S62
E
V
E
E
W
V
A
S
G
N
K
R
P
H
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZKA5
337
36393
A58
E
V
E
Q
W
V
A
A
G
N
K
R
P
H
L
Frog
Xenopus laevis
NP_001086806
335
36223
A56
E
V
E
Q
W
V
A
A
G
N
K
R
P
H
L
Zebra Danio
Brachydanio rerio
NP_001002181
338
36917
A56
D
V
E
E
W
V
S
A
G
N
R
R
P
H
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q04448
309
33532
A57
P
A
S
E
K
Y
V
A
N
K
M
V
A
C
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793717
336
36041
Q55
E
T
D
E
W
I
A
Q
G
N
R
A
P
Q
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
47.4
77.8
N.A.
92
90.5
N.A.
N.A.
81.4
79.7
73.7
N.A.
50
N.A.
N.A.
55.1
Protein Similarity:
100
99.7
57.5
82.1
N.A.
96
94.5
N.A.
N.A.
88
88.5
86
N.A.
64.5
N.A.
N.A.
73.4
P-Site Identity:
100
100
66.6
100
N.A.
100
100
N.A.
N.A.
86.6
86.6
73.3
N.A.
6.6
N.A.
N.A.
53.3
P-Site Similarity:
100
100
80
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
13.3
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
73
37
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% C
% Asp:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
73
0
82
73
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
91
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
82
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
10
0
0
0
0
10
64
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
91
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
91
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
0
0
91
0
0
% P
% Gln:
0
0
0
19
0
0
0
10
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
28
82
0
0
10
% R
% Ser:
0
0
10
10
0
0
19
46
0
0
0
0
0
0
0
% S
% Thr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
82
0
0
0
82
10
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
91
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _