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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD2
All Species:
39.7
Human Site:
S81
Identified Species:
87.33
UniProt:
P13995
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13995
NP_006627.2
350
37895
S81
L
V
G
E
N
P
A
S
H
S
Y
V
L
N
K
Chimpanzee
Pan troglodytes
XP_515555
350
37849
S81
L
V
G
E
N
P
A
S
H
S
Y
V
L
N
K
Rhesus Macaque
Macaca mulatta
XP_001091218
502
54417
S250
L
V
G
D
N
P
A
S
H
T
Y
V
R
N
K
Dog
Lupus familis
XP_540223
398
43317
S129
L
V
G
E
N
P
A
S
H
S
Y
V
L
N
K
Cat
Felis silvestris
Mouse
Mus musculus
P18155
350
37844
S81
L
V
G
D
N
P
A
S
H
S
Y
V
L
N
K
Rat
Rattus norvegicus
NP_001102868
349
37698
S80
L
V
G
D
N
P
A
S
H
S
Y
V
L
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZKA5
337
36393
S76
L
V
G
E
N
P
A
S
H
S
Y
V
L
N
K
Frog
Xenopus laevis
NP_001086806
335
36223
S74
L
V
G
D
N
P
A
S
H
S
Y
V
L
N
K
Zebra Danio
Brachydanio rerio
NP_001002181
338
36917
S74
L
V
G
D
N
P
A
S
H
S
Y
V
L
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q04448
309
33532
L75
I
S
S
E
T
K
R
L
P
A
S
T
T
Q
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793717
336
36041
S73
L
V
G
E
D
P
A
S
S
V
Y
V
K
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
47.4
77.8
N.A.
92
90.5
N.A.
N.A.
81.4
79.7
73.7
N.A.
50
N.A.
N.A.
55.1
Protein Similarity:
100
99.7
57.5
82.1
N.A.
96
94.5
N.A.
N.A.
88
88.5
86
N.A.
64.5
N.A.
N.A.
73.4
P-Site Identity:
100
100
80
100
N.A.
93.3
93.3
N.A.
N.A.
100
93.3
93.3
N.A.
6.6
N.A.
N.A.
73.3
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
26.6
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
91
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
46
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
55
0
0
0
0
0
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
91
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
82
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
91
% K
% Leu:
91
0
0
0
0
0
0
10
0
0
0
0
73
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
82
0
0
0
0
0
0
0
0
91
0
% N
% Pro:
0
0
0
0
0
91
0
0
10
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% R
% Ser:
0
10
10
0
0
0
0
91
10
73
10
0
0
0
0
% S
% Thr:
0
0
0
0
10
0
0
0
0
10
0
10
10
0
0
% T
% Val:
0
91
0
0
0
0
0
0
0
10
0
91
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
91
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _