KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B1
All Species:
23.33
Human Site:
Y254
Identified Species:
73.33
UniProt:
P14061
Number Species:
7
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14061
NP_000404
328
34980
Y254
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
Chimpanzee
Pan troglodytes
Q1WNP0
328
34870
Y254
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
Rhesus Macaque
Macaca mulatta
NP_001040597
320
34258
Y254
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
Dog
Lupus familis
XP_849399
302
32325
Y254
A
P
R
P
A
L
R
Y
F
S
T
E
R
F
L
Cat
Felis silvestris
Mouse
Mus musculus
P51656
344
36767
Y253
A
P
Q
P
A
L
R
Y
F
S
T
N
R
F
L
Rat
Rattus norvegicus
P51657
344
36949
Y253
A
P
Q
P
A
L
R
Y
F
S
T
N
R
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506046
316
35562
Y254
A
P
S
P
P
F
R
Y
Q
T
N
S
V
Y
T
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796670
252
27642
D206
V
N
D
L
P
T
F
D
F
A
L
Q
L
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
93.2
71.9
N.A.
65.6
66.8
N.A.
39.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.2
Protein Similarity:
100
99.6
94.2
77.7
N.A.
74.4
75.2
N.A.
54.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
48.7
P-Site Identity:
100
100
100
80
N.A.
73.3
73.3
N.A.
40
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
88
0
0
0
38
0
0
0
0
13
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
13
0
0
0
0
13
0
0
0
0
0
13
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
50
0
0
0
% E
% Phe:
0
0
0
0
0
13
13
0
88
0
0
0
0
75
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
38
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
13
0
75
0
0
0
0
13
0
13
0
75
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
13
0
0
0
0
0
0
0
0
13
25
0
0
0
% N
% Pro:
0
88
0
88
25
0
0
0
0
0
0
0
0
0
13
% P
% Gln:
0
0
25
0
0
0
0
0
13
0
0
13
0
0
0
% Q
% Arg:
0
0
13
0
0
0
88
0
0
0
0
0
75
0
0
% R
% Ser:
0
0
13
0
0
0
0
0
0
38
0
13
0
0
0
% S
% Thr:
0
0
0
0
38
13
0
0
0
50
75
0
0
0
13
% T
% Val:
13
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
88
0
0
0
0
0
13
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _