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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSE All Species: 10
Human Site: Y223 Identified Species: 27.5
UniProt: P14091 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P14091 NP_001901.1 401 43312 Y223 D L P M F S V Y M S S N P E G
Chimpanzee Pan troglodytes XP_514145 392 42339 S220 P M F S V Y M S S N P E G G A
Rhesus Macaque Macaca mulatta P11489 388 41678 A219 L F S V Y L S A D D Q S G S V
Dog Lupus familis XP_545694 428 46756 Y250 D I P M F S V Y M S S D P E G
Cat Felis silvestris
Mouse Mus musculus P70269 397 42914 S222 M F S V Y L S S D P Q G G S G
Rat Rattus norvegicus P16228 398 43003 S223 M F S V Y L S S D P Q G G S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P16476 383 41701 S218 N L F S V Y L S R E P M G S M
Frog Xenopus laevis Q805F3 397 42889 N218 F S V Y M S R N P N S A V G G
Zebra Danio Brachydanio rerio NP_571879 416 46089 T228 P V F S F Y L T N N G S G F G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.2 52.8 82.2 N.A. 81.8 82.7 N.A. N.A. 51.8 67.8 47.5 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 97.2 69.3 86.4 N.A. 88.5 89.5 N.A. N.A. 67.5 78 66.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 0 86.6 N.A. 6.6 6.6 N.A. N.A. 6.6 20 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 20 100 N.A. 20 20 N.A. N.A. 20 26.6 40 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 12 0 0 0 12 0 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 23 0 0 0 0 0 0 0 34 12 0 12 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 12 0 12 0 23 0 % E
% Phe: 12 34 34 0 34 0 0 0 0 0 0 0 0 12 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 12 23 67 23 67 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 12 23 0 0 0 34 23 0 0 0 0 0 0 0 0 % L
% Met: 23 12 0 23 12 0 12 0 23 0 0 12 0 0 12 % M
% Asn: 12 0 0 0 0 0 0 12 12 34 0 12 0 0 0 % N
% Pro: 23 0 23 0 0 0 0 0 12 23 23 0 23 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 34 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 12 0 12 0 0 0 0 0 0 % R
% Ser: 0 12 34 34 0 34 34 45 12 23 34 23 0 45 0 % S
% Thr: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % T
% Val: 0 12 12 34 23 0 23 0 0 0 0 0 12 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 12 34 34 0 23 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _