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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EDN3
All Species:
6.67
Human Site:
S181
Identified Species:
29.33
UniProt:
P14138
Number Species:
5
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14138
NP_000105.1
238
25454
S181
T
Q
T
L
D
V
S
S
N
S
R
T
A
E
K
Chimpanzee
Pan troglodytes
XP_001140677
238
25367
S181
T
Q
T
L
D
V
S
S
N
S
R
T
A
E
K
Rhesus Macaque
Macaca mulatta
XP_001082213
230
24734
T177
D
V
S
S
N
S
R
T
A
E
K
T
D
K
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P48299
214
23304
C161
W
T
R
L
R
C
T
C
M
G
A
D
D
K
A
Rat
Rattus norvegicus
P13207
167
18434
R114
S
S
P
Q
T
R
L
R
C
A
C
S
G
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001231488
205
23116
Q152
K
R
S
T
G
Q
N
Q
S
T
S
Q
P
S
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
92.8
N.A.
N.A.
53.7
46.6
N.A.
N.A.
34.4
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
94.1
N.A.
N.A.
62.1
53.7
N.A.
N.A.
45.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
N.A.
N.A.
6.6
0
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
46.6
N.A.
N.A.
20
20
N.A.
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
17
17
17
0
34
0
17
% A
% Cys:
0
0
0
0
0
17
0
17
17
0
17
0
0
0
0
% C
% Asp:
17
0
0
0
34
0
0
0
0
0
0
17
34
0
17
% D
% Glu:
0
0
0
0
0
0
0
0
0
17
0
0
0
34
17
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
17
% F
% Gly:
0
0
0
0
17
0
0
0
0
17
0
0
17
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
17
0
0
0
0
0
0
0
0
0
17
0
0
34
34
% K
% Leu:
0
0
0
50
0
0
17
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
17
0
17
0
34
0
0
0
0
0
0
% N
% Pro:
0
0
17
0
0
0
0
0
0
0
0
0
17
0
0
% P
% Gln:
0
34
0
17
0
17
0
17
0
0
0
17
0
0
0
% Q
% Arg:
0
17
17
0
17
17
17
17
0
0
34
0
0
0
0
% R
% Ser:
17
17
34
17
0
17
34
34
17
34
17
17
0
17
0
% S
% Thr:
34
17
34
17
17
0
17
17
0
17
0
50
0
0
0
% T
% Val:
0
17
0
0
0
34
0
0
0
0
0
0
0
17
0
% V
% Trp:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _