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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HGF
All Species:
22.73
Human Site:
Y176
Identified Species:
50
UniProt:
P14210
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14210
NP_000592.3
728
83134
Y176
G
K
D
L
Q
E
N
Y
C
R
N
P
R
G
E
Chimpanzee
Pan troglodytes
XP_519174
728
83101
Y176
G
K
D
L
Q
E
N
Y
C
R
N
P
R
G
E
Rhesus Macaque
Macaca mulatta
P12545
810
90237
T248
P
R
P
W
C
F
T
T
D
P
N
K
R
W
E
Dog
Lupus familis
XP_541884
712
80219
D164
F
C
R
N
P
D
R
D
P
G
G
P
W
C
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q08048
728
82926
Y177
G
K
D
L
Q
E
N
Y
C
R
N
P
R
G
E
Rat
Rattus norvegicus
P17945
728
82887
Y177
G
K
D
L
Q
E
N
Y
C
R
N
P
R
G
E
Wallaby
Macropus eugenll
O18783
806
90963
E240
Y
C
R
N
P
D
G
E
P
R
P
W
C
F
T
Platypus
Ornith. anatinus
XP_001506451
860
97099
R195
D
L
Q
E
N
Y
C
R
N
P
R
G
E
E
G
Chicken
Gallus gallus
NP_001025541
726
82881
Y172
G
K
D
L
R
E
N
Y
C
R
N
P
R
G
E
Frog
Xenopus laevis
NP_001081677
716
81953
Y164
W
P
E
L
E
E
N
Y
C
R
N
P
D
S
D
Zebra Danio
Brachydanio rerio
NP_001013292
699
79162
R163
D
L
R
Q
N
F
C
R
N
P
D
N
D
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
34.4
43.8
N.A.
90.6
90.2
36.8
66.9
75
43.2
45.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
49.7
59
N.A.
96
95.8
52.9
74.7
87.5
60.7
63.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
20
6.6
N.A.
100
100
6.6
0
93.3
53.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
26.6
13.3
N.A.
100
100
13.3
0
100
73.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
19
0
0
10
0
19
0
55
0
0
0
10
10
0
% C
% Asp:
19
0
46
0
0
19
0
10
10
0
10
0
19
0
10
% D
% Glu:
0
0
10
10
10
55
0
10
0
0
0
0
10
10
55
% E
% Phe:
10
0
0
0
0
19
0
0
0
0
0
0
0
10
0
% F
% Gly:
46
0
0
0
0
0
10
0
0
10
10
10
0
46
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
46
0
0
0
0
0
0
0
0
0
10
0
0
0
% K
% Leu:
0
19
0
55
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
19
19
0
55
0
19
0
64
10
0
0
10
% N
% Pro:
10
10
10
0
19
0
0
0
19
28
10
64
0
10
0
% P
% Gln:
0
0
10
10
37
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
28
0
10
0
10
19
0
64
10
0
55
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% S
% Thr:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
10
0
0
10
0
0
0
0
0
0
0
10
10
10
0
% W
% Tyr:
10
0
0
0
0
10
0
55
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _