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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRF1
All Species:
14.55
Human Site:
T186
Identified Species:
35.56
UniProt:
P14222
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14222
NP_001076585.1
555
61377
T186
Y
S
F
H
V
V
H
T
P
P
L
H
P
D
F
Chimpanzee
Pan troglodytes
XP_507837
555
61277
T186
Y
S
F
H
V
V
H
T
P
P
L
H
P
D
F
Rhesus Macaque
Macaca mulatta
XP_001107909
555
61207
T186
Y
S
Y
H
V
V
H
T
P
P
L
H
P
D
F
Dog
Lupus familis
XP_546148
613
68104
S244
Y
S
F
H
L
V
H
S
P
P
L
H
P
N
F
Cat
Felis silvestris
Mouse
Mus musculus
P10820
554
62062
K185
Y
S
F
R
L
V
Q
K
P
P
L
H
L
D
F
Rat
Rattus norvegicus
P35763
554
61495
K185
Y
S
F
R
L
A
Q
K
P
P
L
H
P
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517199
556
61970
M186
Y
R
F
R
L
I
Q
M
P
P
L
E
F
D
F
Chicken
Gallus gallus
XP_425355
491
53999
R132
L
L
A
L
E
Q
P
R
I
S
A
S
H
K
P
Frog
Xenopus laevis
NP_001088381
532
60493
T167
K
L
H
L
D
K
Y
T
F
L
S
H
K
F
E
Zebra Danio
Brachydanio rerio
XP_001341008
580
64816
V179
Y
R
V
S
N
K
P
V
L
H
P
E
F
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
95.5
68.8
N.A.
68.4
69
N.A.
58.6
34.5
33.6
37
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.2
96.7
78.7
N.A.
81
81.8
N.A.
74
50
55.5
58.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
66.6
66.6
N.A.
46.6
0
13.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
73.3
73.3
N.A.
60
0
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
10
0
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
0
0
0
60
0
% D
% Glu:
0
0
0
0
10
0
0
0
0
0
0
20
0
0
10
% E
% Phe:
0
0
60
0
0
0
0
0
10
0
0
0
20
10
70
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
10
40
0
0
40
0
0
10
0
70
10
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
20
0
20
0
0
0
0
10
20
0
% K
% Leu:
10
20
0
20
40
0
0
0
10
10
70
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
20
0
70
70
10
0
50
0
10
% P
% Gln:
0
0
0
0
0
10
30
0
0
0
0
0
0
0
0
% Q
% Arg:
0
20
0
30
0
0
0
10
0
0
0
0
0
0
10
% R
% Ser:
0
60
0
10
0
0
0
10
0
10
10
10
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
40
0
0
0
0
0
0
0
% T
% Val:
0
0
10
0
30
50
0
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
80
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _