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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRF1 All Species: 16.06
Human Site: T452 Identified Species: 39.26
UniProt: P14222 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P14222 NP_001076585.1 555 61377 T452 G Q E L R T S T V W D N N N P
Chimpanzee Pan troglodytes XP_507837 555 61277 T452 G Q E L R T S T V W D N N N P
Rhesus Macaque Macaca mulatta XP_001107909 555 61207 T452 G Q E L R T N T Q W S N N N P
Dog Lupus familis XP_546148 613 68104 T510 G Q E Q R T Y T V W N N N N P
Cat Felis silvestris
Mouse Mus musculus P10820 554 62062 V451 G Q E F R T G V V W N N N N P
Rat Rattus norvegicus P35763 554 61495 V451 G Q E I R T G V V W N N N H P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517199 556 61970 T452 G F E Q R T P T I W N N N N P
Chicken Gallus gallus XP_425355 491 53999 R390 L L Y F N G Q R V R T A T V W
Frog Xenopus laevis NP_001088381 532 60493 N430 S S T D S Y V N F Y F N G Y E
Zebra Danio Brachydanio rerio XP_001341008 580 64816 M444 V K I G S T N M I P N N N S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 95.5 68.8 N.A. 68.4 69 N.A. 58.6 34.5 33.6 37 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.2 96.7 78.7 N.A. 81 81.8 N.A. 74 50 55.5 58.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 80 80 N.A. 73.3 66.6 N.A. 66.6 6.6 6.6 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 86.6 86.6 N.A. 80 86.6 N.A. 80 6.6 13.3 60 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 0 0 0 0 0 20 0 0 0 0 % D
% Glu: 0 0 70 0 0 0 0 0 0 0 0 0 0 0 10 % E
% Phe: 0 10 0 20 0 0 0 0 10 0 10 0 0 0 0 % F
% Gly: 70 0 0 10 0 10 20 0 0 0 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 10 10 0 0 0 0 20 0 0 0 0 0 0 % I
% Lys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 10 0 30 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 20 10 0 0 50 90 80 60 0 % N
% Pro: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 80 % P
% Gln: 0 60 0 20 0 0 10 0 10 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 70 0 0 10 0 10 0 0 0 0 0 % R
% Ser: 10 10 0 0 20 0 20 0 0 0 10 0 0 10 0 % S
% Thr: 0 0 10 0 0 80 0 50 0 0 10 0 10 0 0 % T
% Val: 10 0 0 0 0 0 10 20 60 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 70 0 0 0 0 10 % W
% Tyr: 0 0 10 0 0 10 10 0 0 10 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _