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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HCLS1
All Species:
6.06
Human Site:
Y397
Identified Species:
13.33
UniProt:
P14317
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14317
NP_005326.2
486
53984
Y397
E
D
E
P
E
G
D
Y
E
E
V
L
E
P
E
Chimpanzee
Pan troglodytes
XP_001165524
484
53756
G395
E
Q
E
D
E
P
E
G
D
Y
E
E
V
L
E
Rhesus Macaque
Macaca mulatta
XP_001111514
475
52848
Y391
E
D
E
P
E
G
D
Y
E
E
V
L
E
P
E
Dog
Lupus familis
XP_863432
467
52116
S375
A
D
Y
Q
D
A
S
S
Q
Q
G
L
A
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
P49710
486
54194
R396
E
D
V
G
E
L
D
R
Q
D
E
D
A
E
G
Rat
Rattus norvegicus
Q9JHL4
436
48594
P359
E
P
P
P
V
Q
Q
P
G
A
G
S
G
H
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507265
462
52591
L374
E
A
I
S
Q
Q
E
L
A
Y
E
P
E
T
V
Chicken
Gallus gallus
Q01406
563
63311
G463
E
S
G
Y
K
T
T
G
S
D
Y
Q
E
A
V
Frog
Xenopus laevis
Q6GM14
376
42749
I299
D
A
T
E
N
Q
N
I
Y
E
D
T
P
Q
E
Zebra Danio
Brachydanio rerio
NP_001004121
504
56595
Q413
S
H
V
Y
E
L
E
Q
H
A
A
E
H
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VU84
531
58711
R429
Q
E
Q
E
E
E
V
R
T
K
V
S
V
T
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
94.6
45.2
N.A.
85.1
23
N.A.
33.3
41.3
23.8
43.4
N.A.
21.2
N.A.
N.A.
N.A.
Protein Similarity:
100
99.3
95.4
61.1
N.A.
90.5
37.2
N.A.
51
58
40.3
60.7
N.A.
37.2
N.A.
N.A.
N.A.
P-Site Identity:
100
26.6
100
13.3
N.A.
26.6
13.3
N.A.
13.3
13.3
13.3
6.6
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
100
33.3
N.A.
40
13.3
N.A.
26.6
26.6
26.6
13.3
N.A.
40
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
19
0
0
0
10
0
0
10
19
10
0
19
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
37
0
10
10
0
28
0
10
19
10
10
0
0
0
% D
% Glu:
64
10
28
19
55
10
28
0
19
28
28
19
37
10
37
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
10
0
19
0
19
10
0
19
0
10
0
10
% G
% His:
0
10
0
0
0
0
0
0
10
0
0
0
10
10
10
% H
% Ile:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
19
0
10
0
0
0
28
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
10
28
0
10
0
10
0
0
0
10
10
19
0
% P
% Gln:
10
10
10
10
10
28
10
10
19
10
0
10
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% R
% Ser:
10
10
0
10
0
0
10
10
10
0
0
19
0
0
0
% S
% Thr:
0
0
10
0
0
10
10
0
10
0
0
10
0
28
0
% T
% Val:
0
0
19
0
10
0
10
0
0
0
28
0
19
0
28
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
19
0
0
0
19
10
19
10
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _