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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PKM2 All Species: 22.12
Human Site: S406 Identified Species: 37.44
UniProt: P14618 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.31
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P14618 NP_002645.3 531 57937 S406 R R L A P I T S D P T E A T A
Chimpanzee Pan troglodytes XP_001175096 591 64575 S466 R R L A P I T S D P T E A T A
Rhesus Macaque Macaca mulatta XP_001091427 591 64502 S466 R R L A P I T S D P T E A T A
Dog Lupus familis XP_535531 531 57848 S406 R R L A P I T S D P T E A A A
Cat Felis silvestris
Mouse Mus musculus P52480 531 57826 S406 R R L A P I T S D P T E A A A
Rat Rattus norvegicus P11980 531 57799 T406 A R A S S Q S T D P L E A M A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P00548 530 57996 R405 L R H S V H H R E P A D A M A
Frog Xenopus laevis Q92122 527 57507 R402 R R V S P L T R D P T E A T A
Zebra Danio Brachydanio rerio NP_955365 532 58039 R407 R R S S V L T R D P S D A V A
Tiger Blowfish Takifugu rubipres NP_001027734 531 58206 R406 R R H T Q L T R D P S E A V A
Fruit Fly Dros. melanogaster O62619 533 57422 I408 L V R G A G T I D A S H A A A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O65595 497 54301 M363 M L H A A V P M S P M E S L A
Baker's Yeast Sacchar. cerevisiae P00549 500 54526 T376 R N C T P K P T S T T E T V A
Red Bread Mold Neurospora crassa Q7RVA8 527 57852 V389 C S L A K R P V S I V E S C A
Conservation
Percent
Protein Identity: 100 89.8 89.6 98.4 N.A. 97.7 93.7 N.A. N.A. 86.4 88.8 81.7 82.4 63.4 N.A. N.A. N.A.
Protein Similarity: 100 89.8 89.8 99 N.A. 98.3 96.6 N.A. N.A. 92.6 93.9 90.4 90.5 77.4 N.A. N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 40 N.A. N.A. 26.6 73.3 46.6 53.3 26.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 60 N.A. N.A. 46.6 93.3 73.3 66.6 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 43.8 49.5 49.3
Protein Similarity: N.A. N.A. N.A. 60 65.7 64
P-Site Identity: N.A. N.A. N.A. 26.6 33.3 26.6
P-Site Similarity: N.A. N.A. N.A. 40 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 50 15 0 0 0 0 8 8 0 79 22 100 % A
% Cys: 8 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 0 0 72 0 0 15 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 8 0 0 79 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 22 0 0 8 8 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 0 0 36 0 8 0 8 0 0 0 0 0 % I
% Lys: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % K
% Leu: 15 8 43 0 0 22 0 0 0 0 8 0 0 8 0 % L
% Met: 8 0 0 0 0 0 0 8 0 0 8 0 0 15 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 50 0 22 0 0 79 0 0 0 0 0 % P
% Gln: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 65 72 8 0 0 8 0 29 0 0 0 0 0 0 0 % R
% Ser: 0 8 8 29 8 0 8 36 22 0 22 0 15 0 0 % S
% Thr: 0 0 0 15 0 0 65 15 0 8 50 0 8 29 0 % T
% Val: 0 8 8 0 15 8 0 8 0 0 8 0 0 22 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _