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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PKM2
All Species:
53.33
Human Site:
S437
Identified Species:
90.26
UniProt:
P14618
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14618
NP_002645.3
531
57937
S437
V
L
T
K
S
G
R
S
A
H
Q
V
A
R
Y
Chimpanzee
Pan troglodytes
XP_001175096
591
64575
S497
V
L
T
K
S
G
R
S
A
H
Q
V
A
R
Y
Rhesus Macaque
Macaca mulatta
XP_001091427
591
64502
S497
V
L
T
K
S
G
R
S
A
H
Q
V
A
R
Y
Dog
Lupus familis
XP_535531
531
57848
S437
V
L
T
K
S
G
R
S
A
H
Q
V
A
R
Y
Cat
Felis silvestris
Mouse
Mus musculus
P52480
531
57826
S437
V
L
T
K
S
G
R
S
A
H
Q
V
A
R
Y
Rat
Rattus norvegicus
P11980
531
57799
S437
V
L
T
E
S
G
R
S
A
H
Q
V
A
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P00548
530
57996
S436
V
M
T
E
S
G
R
S
A
H
L
V
S
R
Y
Frog
Xenopus laevis
Q92122
527
57507
S433
V
L
T
K
S
G
R
S
A
H
L
L
S
R
Y
Zebra Danio
Brachydanio rerio
NP_955365
532
58039
S438
I
L
T
K
T
G
R
S
A
H
L
I
S
R
Y
Tiger Blowfish
Takifugu rubipres
NP_001027734
531
58206
S437
V
L
T
K
T
G
R
S
A
H
L
I
S
R
Y
Fruit Fly
Dros. melanogaster
O62619
533
57422
S439
V
I
T
T
S
G
K
S
A
F
Q
V
S
K
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65595
497
54301
T394
V
L
T
R
G
G
S
T
A
R
L
V
A
K
Y
Baker's Yeast
Sacchar. cerevisiae
P00549
500
54526
T407
V
L
S
T
S
G
T
T
P
R
L
V
S
K
Y
Red Bread Mold
Neurospora crassa
Q7RVA8
527
57852
S420
V
L
S
T
S
G
E
S
A
R
L
I
S
K
Y
Conservation
Percent
Protein Identity:
100
89.8
89.6
98.4
N.A.
97.7
93.7
N.A.
N.A.
86.4
88.8
81.7
82.4
63.4
N.A.
N.A.
N.A.
Protein Similarity:
100
89.8
89.8
99
N.A.
98.3
96.6
N.A.
N.A.
92.6
93.9
90.4
90.5
77.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
73.3
80
66.6
73.3
60
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
93.3
93.3
86.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.8
49.5
49.3
Protein Similarity:
N.A.
N.A.
N.A.
60
65.7
64
P-Site Identity:
N.A.
N.A.
N.A.
53.3
40
46.6
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
66.6
73.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
93
0
0
0
50
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
15
0
0
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
100
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
72
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
0
0
0
0
0
22
0
0
0
% I
% Lys:
0
0
0
58
0
0
8
0
0
0
0
0
0
29
0
% K
% Leu:
0
86
0
0
0
0
0
0
0
0
50
8
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
50
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
72
0
0
22
0
0
0
72
0
% R
% Ser:
0
0
15
0
79
0
8
86
0
0
0
0
50
0
0
% S
% Thr:
0
0
86
22
15
0
8
15
0
0
0
0
0
0
0
% T
% Val:
93
0
0
0
0
0
0
0
0
0
0
72
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _