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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PKM2
All Species:
32.12
Human Site:
T405
Identified Species:
54.36
UniProt:
P14618
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14618
NP_002645.3
531
57937
T405
L
R
R
L
A
P
I
T
S
D
P
T
E
A
T
Chimpanzee
Pan troglodytes
XP_001175096
591
64575
T465
L
R
R
L
A
P
I
T
S
D
P
T
E
A
T
Rhesus Macaque
Macaca mulatta
XP_001091427
591
64502
T465
L
R
R
L
A
P
I
T
S
D
P
T
E
A
T
Dog
Lupus familis
XP_535531
531
57848
T405
L
R
R
L
A
P
I
T
S
D
P
T
E
A
A
Cat
Felis silvestris
Mouse
Mus musculus
P52480
531
57826
T405
L
R
R
L
A
P
I
T
S
D
P
T
E
A
A
Rat
Rattus norvegicus
P11980
531
57799
S405
L
A
R
A
S
S
Q
S
T
D
P
L
E
A
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P00548
530
57996
H404
I
L
R
H
S
V
H
H
R
E
P
A
D
A
M
Frog
Xenopus laevis
Q92122
527
57507
T401
L
R
R
V
S
P
L
T
R
D
P
T
E
A
T
Zebra Danio
Brachydanio rerio
NP_955365
532
58039
T406
L
R
R
S
S
V
L
T
R
D
P
S
D
A
V
Tiger Blowfish
Takifugu rubipres
NP_001027734
531
58206
T405
L
R
R
H
T
Q
L
T
R
D
P
S
E
A
V
Fruit Fly
Dros. melanogaster
O62619
533
57422
T407
D
L
V
R
G
A
G
T
I
D
A
S
H
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65595
497
54301
P362
I
M
L
H
A
A
V
P
M
S
P
M
E
S
L
Baker's Yeast
Sacchar. cerevisiae
P00549
500
54526
P375
M
R
N
C
T
P
K
P
T
S
T
T
E
T
V
Red Bread Mold
Neurospora crassa
Q7RVA8
527
57852
P388
L
C
S
L
A
K
R
P
V
S
I
V
E
S
C
Conservation
Percent
Protein Identity:
100
89.8
89.6
98.4
N.A.
97.7
93.7
N.A.
N.A.
86.4
88.8
81.7
82.4
63.4
N.A.
N.A.
N.A.
Protein Similarity:
100
89.8
89.8
99
N.A.
98.3
96.6
N.A.
N.A.
92.6
93.9
90.4
90.5
77.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
40
N.A.
N.A.
20
73.3
46.6
53.3
20
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
60
N.A.
N.A.
46.6
93.3
73.3
66.6
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.8
49.5
49.3
Protein Similarity:
N.A.
N.A.
N.A.
60
65.7
64
P-Site Identity:
N.A.
N.A.
N.A.
20
26.6
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
40
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
50
15
0
0
0
0
8
8
0
79
22
% A
% Cys:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
0
0
0
0
0
0
0
0
72
0
0
15
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
0
0
79
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
22
0
0
8
8
0
0
0
0
8
0
0
% H
% Ile:
15
0
0
0
0
0
36
0
8
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% K
% Leu:
72
15
8
43
0
0
22
0
0
0
0
8
0
0
8
% L
% Met:
8
8
0
0
0
0
0
0
8
0
0
8
0
0
15
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
50
0
22
0
0
79
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
65
72
8
0
0
8
0
29
0
0
0
0
0
0
% R
% Ser:
0
0
8
8
29
8
0
8
36
22
0
22
0
15
0
% S
% Thr:
0
0
0
0
15
0
0
65
15
0
8
50
0
8
29
% T
% Val:
0
0
8
8
0
15
8
0
8
0
0
8
0
0
22
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _