KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PKM2
All Species:
27.88
Human Site:
Y148
Identified Species:
47.18
UniProt:
P14618
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14618
NP_002645.3
531
57937
Y148
K
I
T
L
D
N
A
Y
M
E
K
C
D
E
N
Chimpanzee
Pan troglodytes
XP_001175096
591
64575
Y208
K
I
T
L
D
N
A
Y
M
E
K
C
D
E
N
Rhesus Macaque
Macaca mulatta
XP_001091427
591
64502
Y208
K
I
T
L
D
N
A
Y
M
E
K
C
D
E
N
Dog
Lupus familis
XP_535531
531
57848
Y148
K
I
T
L
D
N
A
Y
M
E
K
C
D
E
N
Cat
Felis silvestris
Mouse
Mus musculus
P52480
531
57826
Y148
K
I
T
L
D
N
A
Y
M
E
K
C
D
E
N
Rat
Rattus norvegicus
P11980
531
57799
Y148
K
I
T
L
D
N
A
Y
M
E
K
C
D
E
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P00548
530
57996
E149
T
L
D
N
A
F
M
E
N
C
D
E
N
V
L
Frog
Xenopus laevis
Q92122
527
57507
N151
F
Q
E
N
C
D
E
N
V
L
W
V
D
Y
K
Zebra Danio
Brachydanio rerio
NP_955365
532
58039
F149
K
V
T
L
D
D
S
F
M
E
N
C
D
E
D
Tiger Blowfish
Takifugu rubipres
NP_001027734
531
58206
Y148
K
I
T
L
D
D
A
Y
I
E
K
C
S
E
E
Fruit Fly
Dros. melanogaster
O62619
533
57422
F151
K
L
T
T
N
K
E
F
L
E
K
G
S
L
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65595
497
54301
T148
S
C
D
K
E
K
G
T
V
R
C
R
C
E
N
Baker's Yeast
Sacchar. cerevisiae
P00549
500
54526
L150
I
Y
V
D
D
G
V
L
S
F
Q
V
L
E
V
Red Bread Mold
Neurospora crassa
Q7RVA8
527
57852
D160
G
R
I
I
Y
V
D
D
G
V
L
A
F
E
V
Conservation
Percent
Protein Identity:
100
89.8
89.6
98.4
N.A.
97.7
93.7
N.A.
N.A.
86.4
88.8
81.7
82.4
63.4
N.A.
N.A.
N.A.
Protein Similarity:
100
89.8
89.8
99
N.A.
98.3
96.6
N.A.
N.A.
92.6
93.9
90.4
90.5
77.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
0
6.6
60
73.3
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
13.3
20
93.3
86.6
53.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.8
49.5
49.3
Protein Similarity:
N.A.
N.A.
N.A.
60
65.7
64
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
50
0
0
0
0
8
0
0
0
% A
% Cys:
0
8
0
0
8
0
0
0
0
8
8
58
8
0
0
% C
% Asp:
0
0
15
8
65
22
8
8
0
0
8
0
58
0
8
% D
% Glu:
0
0
8
0
8
0
15
8
0
65
0
8
0
79
15
% E
% Phe:
8
0
0
0
0
8
0
15
0
8
0
0
8
0
0
% F
% Gly:
8
0
0
0
0
8
8
0
8
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
50
8
8
0
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
65
0
0
8
0
15
0
0
0
0
58
0
0
0
8
% K
% Leu:
0
15
0
58
0
0
0
8
8
8
8
0
8
8
8
% L
% Met:
0
0
0
0
0
0
8
0
50
0
0
0
0
0
0
% M
% Asn:
0
0
0
15
8
43
0
8
8
0
8
0
8
0
50
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
0
8
0
0
0
% R
% Ser:
8
0
0
0
0
0
8
0
8
0
0
0
15
0
0
% S
% Thr:
8
0
65
8
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
8
8
0
0
8
8
0
15
8
0
15
0
8
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
8
0
0
8
0
0
50
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _