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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PKM2
All Species:
18.18
Human Site:
Y390
Identified Species:
30.77
UniProt:
P14618
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14618
NP_002645.3
531
57937
Y390
R
E
A
E
A
A
I
Y
H
L
Q
L
F
E
E
Chimpanzee
Pan troglodytes
XP_001175096
591
64575
Y450
R
E
A
E
A
A
I
Y
H
L
Q
L
F
E
E
Rhesus Macaque
Macaca mulatta
XP_001091427
591
64502
Y450
R
E
A
E
A
A
I
Y
H
L
Q
L
F
E
E
Dog
Lupus familis
XP_535531
531
57848
Y390
R
E
A
E
A
A
I
Y
H
L
Q
L
F
E
E
Cat
Felis silvestris
Mouse
Mus musculus
P52480
531
57826
Y390
R
E
A
E
A
A
I
Y
H
L
Q
L
F
E
E
Rat
Rattus norvegicus
P11980
531
57799
F390
R
E
A
E
A
A
V
F
H
R
L
L
F
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P00548
530
57996
F389
R
E
A
E
A
A
M
F
H
R
Q
Q
F
E
E
Frog
Xenopus laevis
Q92122
527
57507
F386
R
E
A
E
A
A
I
F
H
R
Q
L
F
E
E
Zebra Danio
Brachydanio rerio
NP_955365
532
58039
F391
R
E
A
E
A
A
T
F
H
R
Q
L
F
E
G
Tiger Blowfish
Takifugu rubipres
NP_001027734
531
58206
F390
R
E
A
E
A
A
T
F
H
R
Q
L
F
E
G
Fruit Fly
Dros. melanogaster
O62619
533
57422
L392
C
K
E
A
E
A
A
L
W
H
Q
N
L
F
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65595
497
54301
D347
V
E
A
E
S
T
L
D
Y
G
D
I
F
K
R
Baker's Yeast
Sacchar. cerevisiae
P00549
500
54526
A360
V
I
A
E
Q
A
I
A
Y
L
P
N
Y
D
D
Red Bread Mold
Neurospora crassa
Q7RVA8
527
57852
P373
L
K
A
E
N
T
I
P
Y
V
S
H
F
E
E
Conservation
Percent
Protein Identity:
100
89.8
89.6
98.4
N.A.
97.7
93.7
N.A.
N.A.
86.4
88.8
81.7
82.4
63.4
N.A.
N.A.
N.A.
Protein Similarity:
100
89.8
89.8
99
N.A.
98.3
96.6
N.A.
N.A.
92.6
93.9
90.4
90.5
77.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
73.3
N.A.
N.A.
73.3
86.6
73.3
73.3
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
N.A.
86.6
93.3
80
80
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.8
49.5
49.3
Protein Similarity:
N.A.
N.A.
N.A.
60
65.7
64
P-Site Identity:
N.A.
N.A.
N.A.
26.6
33.3
40
P-Site Similarity:
N.A.
N.A.
N.A.
60
60
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
93
8
72
86
8
8
0
0
0
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
0
8
0
0
8
8
% D
% Glu:
0
79
8
93
8
0
0
0
0
0
0
0
0
79
65
% E
% Phe:
0
0
0
0
0
0
0
36
0
0
0
0
86
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
15
% G
% His:
0
0
0
0
0
0
0
0
72
8
0
8
0
0
0
% H
% Ile:
0
8
0
0
0
0
58
0
0
0
0
8
0
0
0
% I
% Lys:
0
15
0
0
0
0
0
0
0
0
0
0
0
8
0
% K
% Leu:
8
0
0
0
0
0
8
8
0
43
8
65
8
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
15
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
72
8
0
0
0
% Q
% Arg:
72
0
0
0
0
0
0
0
0
36
0
0
0
0
8
% R
% Ser:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
15
15
0
0
0
0
0
0
0
0
% T
% Val:
15
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
36
22
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _