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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90B1
All Species:
34.24
Human Site:
S544
Identified Species:
53.81
UniProt:
P14625
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14625
NP_003290.1
803
92469
S544
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
Chimpanzee
Pan troglodytes
XP_509323
803
92478
S544
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
Rhesus Macaque
Macaca mulatta
XP_001095189
804
92594
S544
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P08113
802
92457
S544
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
Rat
Rattus norvegicus
Q66HD0
804
92752
S544
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507634
816
93562
S560
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
Chicken
Gallus gallus
P08110
795
91537
A543
K
I
Y
F
M
A
G
A
S
R
K
E
A
E
S
Frog
Xenopus laevis
NP_001083114
805
92996
S543
K
I
Y
F
M
A
G
S
S
R
Q
E
V
E
S
Zebra Danio
Brachydanio rerio
Q90474
725
83300
A507
F
V
E
R
L
R
K
A
G
L
E
V
I
Y
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
G500
V
E
R
V
K
A
R
G
F
E
V
V
Y
M
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
G485
V
E
R
V
K
S
R
G
F
E
V
L
Y
M
C
Sea Urchin
Strong. purpuratus
NP_999808
806
92314
T544
V
I
Y
F
V
A
G
T
S
R
K
E
V
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
K498
S
P
F
L
E
R
L
K
K
K
G
Y
E
V
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STX5
823
94185
S574
D
I
F
Y
I
T
G
S
S
K
E
Q
L
E
K
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
K488
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
N.A.
N.A.
96.6
95.1
N.A.
90.5
90.5
85
44.2
N.A.
44.2
N.A.
43.2
65.2
Protein Similarity:
100
99.8
99.7
N.A.
N.A.
98.5
97.8
N.A.
95.4
95.1
94.1
62.5
N.A.
61.3
N.A.
61.5
81.3
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
93.3
86.6
0
N.A.
6.6
N.A.
0
73.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
93.3
26.6
N.A.
13.3
N.A.
6.6
86.6
Percent
Protein Identity:
N.A.
46.8
N.A.
47.7
44.4
N.A.
Protein Similarity:
N.A.
63.1
N.A.
67.8
61.2
N.A.
P-Site Identity:
N.A.
0
N.A.
33.3
6.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
73.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
74
0
14
7
0
0
0
47
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
14
7
0
7
0
0
0
0
14
14
60
14
67
0
% E
% Phe:
7
0
20
60
0
0
0
0
14
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
67
14
7
0
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
67
0
0
7
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
54
0
0
0
14
0
7
14
7
20
54
0
0
0
7
% K
% Leu:
0
0
0
14
7
0
14
0
0
7
0
7
7
0
14
% L
% Met:
0
0
0
0
54
0
0
0
0
0
0
0
0
14
7
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% N
% Pro:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
7
0
0
0
% Q
% Arg:
0
0
14
7
0
14
14
0
0
60
0
0
0
0
0
% R
% Ser:
14
0
0
0
0
7
0
54
67
0
0
0
0
0
60
% S
% Thr:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
7
% T
% Val:
20
7
0
14
7
0
0
0
0
0
14
14
14
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
60
7
0
0
0
0
0
0
0
7
14
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _