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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90B1 All Species: 33.33
Human Site: Y401 Identified Species: 52.38
UniProt: P14625 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P14625 NP_003290.1 803 92469 Y401 P R G L F D E Y G S K K S D Y
Chimpanzee Pan troglodytes XP_509323 803 92478 Y401 P R G L F D E Y G S K K S D Y
Rhesus Macaque Macaca mulatta XP_001095189 804 92594 Y401 P R G L F D E Y G S K K S D Y
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P08113 802 92457 Y401 P R G L F D E Y G S K K S D Y
Rat Rattus norvegicus Q66HD0 804 92752 Y401 P R G L F D E Y G S K K S D Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507634 816 93562 Y417 P R G L F D E Y G S K K S D F
Chicken Gallus gallus P08110 795 91537 Y400 P R G L F D E Y G S K K S D F
Frog Xenopus laevis NP_001083114 805 92996 Y400 P R G L F D E Y G S K K I D F
Zebra Danio Brachydanio rerio Q90474 725 83300 C367 R V F I M D N C E E L I P E Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 E360 V F I M D N C E D L I P E Y L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q18688 702 80265 C345 R V F I M E N C E E L M P E Y
Sea Urchin Strong. purpuratus NP_999808 806 92314 D401 A P N Q M F Q D Y G K K F D N
Poplar Tree Populus trichocarpa
Maize Zea mays Q08277 715 81872 D358 V R R V F I M D N C E E L I P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STX5 823 94185 Y408 P H D L Y E S Y Y N S N K A N
Baker's Yeast Sacchar. cerevisiae P15108 705 80881 D348 V R R V F I T D E A E D L I P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.6 N.A. N.A. 96.6 95.1 N.A. 90.5 90.5 85 44.2 N.A. 44.2 N.A. 43.2 65.2
Protein Similarity: 100 99.8 99.7 N.A. N.A. 98.5 97.8 N.A. 95.4 95.1 94.1 62.5 N.A. 61.3 N.A. 61.5 81.3
P-Site Identity: 100 100 100 N.A. N.A. 100 100 N.A. 93.3 93.3 86.6 13.3 N.A. 0 N.A. 6.6 20
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 100 93.3 26.6 N.A. 13.3 N.A. 26.6 26.6
Percent
Protein Identity: N.A. 46.8 N.A. 47.7 44.4 N.A.
Protein Similarity: N.A. 63.1 N.A. 67.8 61.2 N.A.
P-Site Identity: N.A. 13.3 N.A. 20 13.3 N.A.
P-Site Similarity: N.A. 33.3 N.A. 40 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 7 14 0 7 0 0 0 0 0 % C
% Asp: 0 0 7 0 7 60 0 20 7 0 0 7 0 60 0 % D
% Glu: 0 0 0 0 0 14 54 7 20 14 14 7 7 14 0 % E
% Phe: 0 7 14 0 67 7 0 0 0 0 0 0 7 0 20 % F
% Gly: 0 0 54 0 0 0 0 0 54 7 0 0 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 14 0 14 0 0 0 0 7 7 7 14 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 60 60 7 0 0 % K
% Leu: 0 0 0 60 0 0 0 0 0 7 14 0 14 0 7 % L
% Met: 0 0 0 7 20 0 7 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 7 0 0 7 14 0 7 7 0 7 0 0 14 % N
% Pro: 60 7 0 0 0 0 0 0 0 0 0 7 14 0 14 % P
% Gln: 0 0 0 7 0 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 14 67 14 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 7 0 0 54 7 0 47 0 0 % S
% Thr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % T
% Val: 20 14 0 14 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 60 14 0 0 0 0 7 47 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _