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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDO1
All Species:
25.76
Human Site:
S312
Identified Species:
51.52
UniProt:
P14902
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14902
NP_002155.1
403
45326
S312
N
F
L
C
S
L
E
S
N
P
S
V
R
E
F
Chimpanzee
Pan troglodytes
XP_001137363
403
45217
S312
N
F
L
C
S
L
E
S
N
P
S
V
R
E
F
Rhesus Macaque
Macaca mulatta
NP_001070951
403
45435
S312
N
F
L
Y
S
L
E
S
S
P
S
V
R
E
F
Dog
Lupus familis
XP_532793
407
46194
S316
D
F
L
L
L
L
K
S
G
P
S
V
R
E
F
Cat
Felis silvestris
Mouse
Mus musculus
P28776
407
45623
S316
N
F
L
F
F
L
E
S
A
P
P
V
R
E
F
Rat
Rattus norvegicus
Q9ERD9
407
45812
S316
N
F
L
S
S
L
E
S
A
P
P
V
R
E
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516166
388
42890
I296
A
P
S
L
R
Q
H
I
L
S
S
E
N
S
Q
Chicken
Gallus gallus
XP_424397
362
39942
P272
I
R
D
I
S
R
A
P
S
L
R
Q
H
I
L
Frog
Xenopus laevis
NP_001091286
398
44646
K305
H
F
V
E
R
I
G
K
A
P
S
L
P
G
Y
Zebra Danio
Brachydanio rerio
NP_001077323
435
48931
Q322
L
R
D
F
V
L
Q
Q
A
D
E
R
L
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782741
463
51327
S325
D
L
I
A
A
I
T
S
G
P
S
I
K
D
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P47125
453
50757
S340
E
F
L
Y
H
L
E
S
V
C
N
I
R
E
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
93.5
66.5
N.A.
61.1
62.4
N.A.
42.9
40.2
42.6
42.5
N.A.
N.A.
N.A.
N.A.
28.5
Protein Similarity:
100
99.2
96.2
81
N.A.
76.1
76.6
N.A.
63.2
57
62.5
61.1
N.A.
N.A.
N.A.
N.A.
48.1
P-Site Identity:
100
100
86.6
66.6
N.A.
73.3
80
N.A.
6.6
6.6
20
6.6
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
93.3
80
N.A.
73.3
80
N.A.
6.6
13.3
53.3
13.3
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
9
0
9
0
34
0
0
0
0
0
0
% A
% Cys:
0
0
0
17
0
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
17
0
17
0
0
0
0
0
0
9
0
0
0
9
0
% D
% Glu:
9
0
0
9
0
0
50
0
0
0
9
9
0
59
0
% E
% Phe:
0
67
0
17
9
0
0
0
0
0
0
0
0
0
50
% F
% Gly:
0
0
0
0
0
0
9
0
17
0
0
0
0
9
0
% G
% His:
9
0
0
0
9
0
9
0
0
0
0
0
9
0
9
% H
% Ile:
9
0
9
9
0
17
0
9
0
0
0
17
0
9
0
% I
% Lys:
0
0
0
0
0
0
9
9
0
0
0
0
9
0
0
% K
% Leu:
9
9
59
17
9
67
0
0
9
9
0
9
9
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
42
0
0
0
0
0
0
0
17
0
9
0
9
0
0
% N
% Pro:
0
9
0
0
0
0
0
9
0
67
17
0
9
0
0
% P
% Gln:
0
0
0
0
0
9
9
9
0
0
0
9
0
0
9
% Q
% Arg:
0
17
0
0
17
9
0
0
0
0
9
9
59
0
0
% R
% Ser:
0
0
9
9
42
0
0
67
17
9
59
0
0
9
0
% S
% Thr:
0
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% T
% Val:
0
0
9
0
9
0
0
0
9
0
0
50
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
25
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _