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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IDO1 All Species: 12.42
Human Site: S393 Identified Species: 24.85
UniProt: P14902 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P14902 NP_002155.1 403 45326 S393 N F L K T V R S T T E K S L L
Chimpanzee Pan troglodytes XP_001137363 403 45217 S393 N F L K T V R S T T E K S L L
Rhesus Macaque Macaca mulatta NP_001070951 403 45435 S393 E F L K T V R S T T E K Y R L
Dog Lupus familis XP_532793 407 46194 T397 D F L K S V R T T T E K F L L
Cat Felis silvestris
Mouse Mus musculus P28776 407 45623 D397 T F L R S V K D T T E K A L L
Rat Rattus norvegicus Q9ERD9 407 45812 D397 N F L R S V K D T T K K A L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516166 388 42890 D377 S F L K S V R D T T K E A M I
Chicken Gallus gallus XP_424397 362 39942 D353 I F L K S V R D S T R E G L I
Frog Xenopus laevis NP_001091286 398 44646 K386 K N V R G T C K E G V L N N D
Zebra Danio Brachydanio rerio NP_001077323 435 48931 N403 T F L K T V R N E T K D S S I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782741 463 51327 A406 L R D S T L R A M L R T T R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P47125 453 50757 K421 G H K V A S S K T I G T G G T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 93.5 66.5 N.A. 61.1 62.4 N.A. 42.9 40.2 42.6 42.5 N.A. N.A. N.A. N.A. 28.5
Protein Similarity: 100 99.2 96.2 81 N.A. 76.1 76.6 N.A. 63.2 57 62.5 61.1 N.A. N.A. N.A. N.A. 48.1
P-Site Identity: 100 100 80 73.3 N.A. 60 60 N.A. 46.6 46.6 0 53.3 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 80 93.3 N.A. 86.6 93.3 N.A. 93.3 73.3 20 73.3 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 9 0 0 0 0 25 0 0 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 9 0 0 0 0 34 0 0 0 9 0 0 9 % D
% Glu: 9 0 0 0 0 0 0 0 17 0 42 17 0 0 0 % E
% Phe: 0 75 0 0 0 0 0 0 0 0 0 0 9 0 0 % F
% Gly: 9 0 0 0 9 0 0 0 0 9 9 0 17 9 9 % G
% His: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 25 % I
% Lys: 9 0 9 59 0 0 17 17 0 0 25 50 0 0 0 % K
% Leu: 9 0 75 0 0 9 0 0 0 9 0 9 0 50 50 % L
% Met: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 0 % M
% Asn: 25 9 0 0 0 0 0 9 0 0 0 0 9 9 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 0 25 0 0 67 0 0 0 17 0 0 17 0 % R
% Ser: 9 0 0 9 42 9 9 25 9 0 0 0 25 9 0 % S
% Thr: 17 0 0 0 42 9 0 9 67 75 0 17 9 0 9 % T
% Val: 0 0 9 9 0 75 0 0 0 0 9 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _