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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
10.91
Human Site:
S110
Identified Species:
17.14
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S110
L
G
N
G
T
D
F
S
V
S
S
S
A
S
M
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S110
L
G
N
G
T
D
F
S
V
S
S
S
A
S
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
S87
V
T
S
S
S
S
S
S
L
S
V
L
P
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
I94
G
E
H
N
P
P
S
I
Y
L
E
A
Y
E
E
Rat
Rattus norvegicus
P11345
648
72910
G37
P
T
I
V
Q
Q
F
G
Y
Q
R
R
A
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
I90
G
E
H
N
P
P
S
I
Y
L
E
A
Y
E
E
Chicken
Gallus gallus
Q04982
806
89347
S110
M
G
N
G
T
D
F
S
V
S
S
S
A
S
T
Frog
Xenopus laevis
P09560
638
71941
C27
S
V
F
E
G
S
S
C
M
S
P
T
I
V
H
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
C120
I
G
N
G
T
E
F
C
S
S
P
T
P
T
L
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
P116
M
G
N
G
T
D
F
P
C
S
P
S
P
M
P
Fruit Fly
Dros. melanogaster
P11346
782
88616
E127
L
N
S
Q
D
Q
Q
E
D
S
S
L
V
E
R
Honey Bee
Apis mellifera
XP_396892
715
80060
G94
L
N
A
G
R
V
S
G
S
A
S
T
S
E
S
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
K117
A
I
S
K
L
L
K
K
R
N
I
T
P
Q
L
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
N101
R
I
N
N
E
M
S
N
G
H
T
S
P
N
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
D142
G
F
G
G
G
G
G
D
L
R
I
Q
M
A
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
20
N.A.
0
20
N.A.
0
86.6
6.6
40
53.3
20
20
0
13.3
P-Site Similarity:
100
100
N.A.
46.6
N.A.
13.3
20
N.A.
13.3
93.3
20
73.3
60
26.6
40
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
0
0
0
0
0
7
0
14
27
7
7
% A
% Cys:
0
0
0
0
0
0
0
14
7
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
27
0
7
7
0
0
0
0
0
7
% D
% Glu:
0
14
0
7
7
7
0
7
0
0
14
0
0
27
14
% E
% Phe:
0
7
7
0
0
0
40
0
0
0
0
0
0
0
0
% F
% Gly:
20
34
7
47
14
7
7
14
7
0
0
0
0
0
0
% G
% His:
0
0
14
0
0
0
0
0
0
7
0
0
0
0
7
% H
% Ile:
7
14
7
0
0
0
0
14
0
0
14
0
7
0
0
% I
% Lys:
0
0
0
7
0
0
7
7
0
0
0
0
0
0
0
% K
% Leu:
27
0
0
0
7
7
0
0
14
14
0
14
0
0
20
% L
% Met:
14
0
0
0
0
7
0
0
7
0
0
0
7
7
14
% M
% Asn:
0
14
40
20
0
0
0
7
0
7
0
0
0
7
0
% N
% Pro:
7
0
0
0
14
14
0
7
0
0
20
0
34
0
7
% P
% Gln:
0
0
0
7
7
14
7
0
0
7
0
7
0
7
0
% Q
% Arg:
7
0
0
0
7
0
0
0
7
7
7
7
0
0
7
% R
% Ser:
7
0
20
7
7
14
40
27
14
54
34
34
7
34
14
% S
% Thr:
0
14
0
0
34
0
0
0
0
0
7
27
0
7
7
% T
% Val:
7
7
0
7
0
7
0
0
20
0
7
0
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
20
0
0
0
14
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _