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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
15.76
Human Site:
S125
Identified Species:
24.76
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S125
D
T
V
T
S
S
S
S
S
S
L
S
V
L
P
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S125
D
T
V
T
S
S
S
S
S
S
L
S
V
L
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
T102
L
S
V
F
Q
N
P
T
D
I
S
R
S
N
P
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
L109
Y
T
S
K
L
D
A
L
Q
Q
R
E
Q
Q
L
Rat
Rattus norvegicus
P11345
648
72910
S52
D
G
K
L
T
D
S
S
K
T
S
N
T
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
L105
Y
T
S
K
L
D
A
L
Q
Q
R
E
Q
Q
L
Chicken
Gallus gallus
Q04982
806
89347
S125
D
T
V
A
S
S
S
S
S
S
L
S
V
A
P
Frog
Xenopus laevis
P09560
638
71941
A42
Q
F
G
Y
Q
R
R
A
S
D
D
G
K
L
S
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
I135
L
D
V
K
G
Q
G
I
Q
S
A
P
T
A
P
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
G131
A
L
L
E
V
K
M
G
G
C
V
P
G
V
G
Fruit Fly
Dros. melanogaster
P11346
782
88616
Q142
F
K
E
Q
P
H
Y
Q
N
Q
T
Q
I
L
Q
Honey Bee
Apis mellifera
XP_396892
715
80060
S109
E
S
R
D
A
N
A
S
I
R
G
Q
R
T
P
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
D132
C
H
V
N
A
S
S
D
P
K
Q
E
S
I
E
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
P116
Q
T
T
P
P
P
E
P
A
D
L
H
V
P
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
S157
D
S
A
G
G
S
S
S
G
K
S
W
A
Q
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
13.3
N.A.
6.6
20
N.A.
6.6
86.6
13.3
20
0
6.6
13.3
20
20
P-Site Similarity:
100
100
N.A.
33.3
N.A.
13.3
46.6
N.A.
13.3
86.6
20
20
20
20
46.6
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
7
14
0
20
7
7
0
7
0
7
14
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
34
7
0
7
0
20
0
7
7
14
7
0
0
0
0
% D
% Glu:
7
0
7
7
0
0
7
0
0
0
0
20
0
0
7
% E
% Phe:
7
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
7
7
14
0
7
7
14
0
7
7
7
0
7
% G
% His:
0
7
0
0
0
7
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
7
7
7
0
0
7
14
0
% I
% Lys:
0
7
7
20
0
7
0
0
7
14
0
0
7
0
0
% K
% Leu:
14
7
7
7
14
0
0
14
0
0
27
0
0
27
14
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
14
0
0
7
0
0
7
0
7
0
% N
% Pro:
0
0
0
7
14
7
7
7
7
0
0
14
0
7
40
% P
% Gln:
14
0
0
7
14
7
0
7
20
20
7
14
14
20
14
% Q
% Arg:
0
0
7
0
0
7
7
0
0
7
14
7
7
0
7
% R
% Ser:
0
20
14
0
20
34
40
40
27
27
20
20
14
0
7
% S
% Thr:
0
40
7
14
7
0
0
7
0
7
7
0
14
7
0
% T
% Val:
0
0
40
0
7
0
0
0
0
0
7
0
27
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
14
0
0
7
0
0
7
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _