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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
33.94
Human Site:
S365
Identified Species:
53.33
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S365
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S365
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
S325
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
S348
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Rat
Rattus norvegicus
P11345
648
72910
R275
T
T
L
P
V
D
S
R
M
I
E
D
A
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
S345
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Chicken
Gallus gallus
Q04982
806
89347
S365
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Frog
Xenopus laevis
P09560
638
71941
S265
T
P
N
V
H
M
V
S
T
T
M
A
V
D
S
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
S375
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
S375
G
Q
R
D
R
S
S
S
A
P
N
V
H
I
N
Fruit Fly
Dros. melanogaster
P11346
782
88616
Q383
G
R
P
P
R
I
S
Q
D
D
R
S
N
S
A
Honey Bee
Apis mellifera
XP_396892
715
80060
Q334
I
D
E
Y
T
R
S
Q
S
L
G
R
P
I
G
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
T393
G
S
N
S
P
S
S
T
C
S
S
P
P
G
G
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
F354
D
S
E
A
F
S
R
F
A
F
P
V
K
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
C391
N
R
D
D
A
A
S
C
L
V
R
F
G
L
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
100
N.A.
100
13.3
N.A.
100
100
6.6
100
100
20
13.3
20
20
P-Site Similarity:
100
100
N.A.
100
N.A.
100
13.3
N.A.
100
100
13.3
100
100
33.3
20
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
7
0
0
60
0
0
7
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% C
% Asp:
7
7
7
60
0
7
0
0
7
7
0
7
0
7
7
% D
% Glu:
0
0
14
0
0
0
0
0
0
0
7
0
0
0
0
% E
% Phe:
0
0
0
0
7
0
0
7
0
7
0
7
0
0
0
% F
% Gly:
67
0
0
0
0
0
0
0
0
0
7
0
7
7
14
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
54
0
0
% H
% Ile:
7
0
0
0
0
7
0
0
0
7
0
0
0
67
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% K
% Leu:
0
0
7
0
0
0
0
0
7
7
0
0
0
7
0
% L
% Met:
0
0
0
0
0
7
0
0
7
0
7
0
0
0
0
% M
% Asn:
7
0
14
0
0
0
0
0
0
0
54
0
7
0
54
% N
% Pro:
0
7
7
14
7
0
0
0
0
54
7
7
14
0
0
% P
% Gln:
0
54
0
0
0
0
0
14
0
0
0
0
0
0
0
% Q
% Arg:
0
14
54
0
60
7
7
7
0
0
14
7
0
0
7
% R
% Ser:
0
14
0
7
0
67
87
60
7
7
7
7
0
14
14
% S
% Thr:
14
7
0
0
7
0
0
7
7
7
0
0
0
0
0
% T
% Val:
0
0
0
7
7
0
7
0
0
7
0
60
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _