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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
22.73
Human Site:
S399
Identified Species:
35.71
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S399
G
G
S
T
T
G
L
S
A
T
P
P
A
S
L
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S399
G
G
S
T
T
G
L
S
A
T
P
P
A
S
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
S399
R
G
S
T
T
G
L
S
A
T
P
P
A
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
T436
S
T
T
G
L
S
A
T
P
P
A
S
L
P
G
Rat
Rattus norvegicus
P11345
648
72910
T303
S
P
N
N
L
S
P
T
G
W
S
Q
P
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
S431
R
G
S
T
T
G
L
S
A
T
P
P
A
S
L
Chicken
Gallus gallus
Q04982
806
89347
S439
R
G
S
T
A
G
L
S
A
T
P
P
A
S
L
Frog
Xenopus laevis
P09560
638
71941
P293
G
S
P
N
N
L
S
P
T
G
W
S
N
A
K
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
L409
D
G
G
S
T
T
G
L
S
A
T
P
P
A
S
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
S410
G
G
S
T
T
G
L
S
A
T
P
P
A
S
L
Fruit Fly
Dros. melanogaster
P11346
782
88616
R414
R
S
L
I
M
Q
A
R
P
P
L
P
H
P
C
Honey Bee
Apis mellifera
XP_396892
715
80060
A362
K
H
S
Q
S
T
Q
A
S
P
T
S
T
L
R
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
A423
S
T
T
S
S
L
V
A
A
H
L
H
T
L
P
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
R382
N
L
I
H
S
P
K
R
E
S
G
S
H
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
P422
P
D
S
L
L
N
G
P
S
S
I
S
I
S
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
93.3
N.A.
0
0
N.A.
93.3
86.6
6.6
20
100
6.6
6.6
6.6
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
13.3
13.3
N.A.
93.3
86.6
13.3
40
100
6.6
26.6
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
14
14
47
7
7
0
40
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
27
47
7
7
0
40
14
0
7
7
7
0
0
0
7
% G
% His:
0
7
0
7
0
0
0
0
0
7
0
7
14
0
0
% H
% Ile:
0
0
7
7
0
0
0
0
0
0
7
0
7
0
0
% I
% Lys:
7
0
0
0
0
0
7
0
0
0
0
0
0
7
7
% K
% Leu:
0
7
7
7
20
14
40
7
0
0
14
0
7
14
40
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
7
14
7
7
0
0
0
0
0
0
7
0
0
% N
% Pro:
7
7
7
0
0
7
7
14
14
20
40
54
14
14
7
% P
% Gln:
0
0
0
7
0
7
7
0
0
0
0
7
0
0
0
% Q
% Arg:
27
0
0
0
0
0
0
14
0
0
0
0
0
0
7
% R
% Ser:
20
14
54
14
20
14
7
40
20
14
7
34
0
54
20
% S
% Thr:
0
14
14
40
40
14
0
14
7
40
14
0
14
0
7
% T
% Val:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _