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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
26.67
Human Site:
S428
Identified Species:
41.9
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S428
G
P
Q
R
E
R
K
S
S
S
S
S
E
D
R
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S428
G
P
Q
R
E
R
K
S
S
S
S
S
E
D
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
S428
G
P
Q
R
E
R
K
S
S
S
S
S
E
D
R
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
S465
Q
R
E
R
K
S
S
S
S
S
S
S
E
D
R
Rat
Rattus norvegicus
P11345
648
72910
P332
Q
E
K
N
K
I
R
P
R
G
Q
R
D
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
S460
G
P
Q
R
E
R
K
S
S
S
S
S
E
D
R
Chicken
Gallus gallus
Q04982
806
89347
S468
G
P
Q
R
E
R
K
S
S
S
S
S
E
D
R
Frog
Xenopus laevis
P09560
638
71941
R322
G
Q
E
K
N
K
I
R
A
R
G
Q
R
D
S
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
P438
C
Q
P
R
E
R
K
P
S
S
S
S
E
D
R
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
S439
C
Q
Q
R
E
R
K
S
S
S
S
S
E
D
R
Fruit Fly
Dros. melanogaster
P11346
782
88616
A443
L
K
H
N
R
P
R
A
R
S
A
D
E
S
N
Honey Bee
Apis mellifera
XP_396892
715
80060
S391
N
L
L
A
P
R
E
S
I
E
D
W
E
I
P
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
R452
G
F
F
R
N
R
S
R
S
P
G
E
R
L
D
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
N411
P
G
S
D
S
K
D
N
K
I
K
P
P
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
Q451
D
F
R
L
L
A
K
Q
Y
F
S
D
S
Q
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
100
N.A.
60
0
N.A.
100
100
13.3
73.3
86.6
13.3
20
26.6
0
P-Site Similarity:
100
100
N.A.
100
N.A.
73.3
26.6
N.A.
100
100
40
73.3
86.6
33.3
26.6
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
7
0
7
7
0
7
0
0
0
0
% A
% Cys:
14
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
7
0
0
7
0
0
0
7
14
7
60
7
% D
% Glu:
0
7
14
0
47
0
7
0
0
7
0
7
67
0
0
% E
% Phe:
0
14
7
0
0
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
47
7
0
0
0
0
0
0
0
7
14
0
0
0
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
7
0
7
7
0
0
0
7
0
% I
% Lys:
0
7
7
7
14
14
54
0
7
0
7
0
0
0
0
% K
% Leu:
7
7
7
7
7
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
14
14
0
0
7
0
0
0
0
0
0
7
% N
% Pro:
7
34
7
0
7
7
0
14
0
7
0
7
7
0
7
% P
% Gln:
14
20
40
0
0
0
0
7
0
0
7
7
0
7
0
% Q
% Arg:
0
7
7
60
7
60
14
14
14
7
0
7
14
0
54
% R
% Ser:
0
0
7
0
7
7
14
54
60
60
60
54
7
14
20
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _