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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
36.06
Human Site:
S683
Identified Species:
56.67
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S683
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S683
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
S683
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
S720
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Rat
Rattus norvegicus
P11345
648
72910
M581
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
S715
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Chicken
Gallus gallus
Q04982
806
89347
S723
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Frog
Xenopus laevis
P09560
638
71941
A571
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
S693
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
S694
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
Fruit Fly
Dros. melanogaster
P11346
782
88616
S698
P
D
M
S
Q
V
R
S
D
A
P
Q
A
L
K
Honey Bee
Apis mellifera
XP_396892
715
80060
I642
K
R
L
T
E
D
C
I
K
F
S
R
E
D
R
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
H712
P
D
R
S
K
I
R
H
D
T
P
K
S
M
L
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
N666
P
D
L
S
K
V
R
N
D
T
P
K
A
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
P727
P
E
V
L
R
D
E
P
S
N
E
K
S
D
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
100
100
0
100
100
60
6.6
53.3
73.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
100
100
20
100
100
93.3
33.3
73.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
7
0
7
0
0
74
7
0
% A
% Cys:
0
0
0
7
7
0
7
0
0
54
0
0
0
0
7
% C
% Asp:
0
74
0
0
0
14
0
0
20
0
0
0
0
20
7
% D
% Glu:
0
7
0
0
7
0
7
0
0
0
7
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% I
% Lys:
7
7
7
0
67
7
7
0
14
7
0
74
0
0
67
% K
% Leu:
7
0
67
7
0
0
0
0
0
0
7
7
0
14
7
% L
% Met:
0
0
7
0
0
0
0
7
7
0
0
0
0
60
0
% M
% Asn:
0
0
7
7
0
0
0
7
54
7
0
0
0
0
0
% N
% Pro:
80
0
0
0
7
7
0
7
0
0
74
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% Q
% Arg:
0
7
7
0
7
0
74
0
0
7
7
7
0
0
7
% R
% Ser:
0
0
0
74
0
0
0
60
7
0
7
0
14
0
0
% S
% Thr:
0
0
0
7
0
0
0
0
0
14
0
0
0
0
0
% T
% Val:
0
0
7
0
0
67
0
0
0
0
0
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _