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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
21.21
Human Site:
S76
Identified Species:
33.33
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S76
G
G
E
H
N
P
P
S
I
Y
L
E
A
Y
E
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S76
G
G
E
H
N
P
P
S
I
Y
L
E
A
Y
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
Q53
T
S
K
L
D
A
L
Q
Q
R
E
Q
Q
L
L
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
I60
S
S
A
A
D
P
A
I
P
E
E
V
W
N
I
Rat
Rattus norvegicus
P11345
648
72910
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
L56
V
L
I
P
A
S
P
L
S
C
R
V
W
N
I
Chicken
Gallus gallus
Q04982
806
89347
S76
G
G
E
H
N
P
P
S
I
Y
L
E
A
Y
E
Frog
Xenopus laevis
P09560
638
71941
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
S86
G
G
E
H
N
P
P
S
I
Y
L
E
A
Y
E
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
T82
G
G
E
H
N
P
P
T
I
Y
L
E
A
Y
E
Fruit Fly
Dros. melanogaster
P11346
782
88616
W93
Y
V
C
I
S
R
L
W
F
L
P
T
E
Y
Q
Honey Bee
Apis mellifera
XP_396892
715
80060
S60
A
G
F
Q
H
P
P
S
I
Y
L
N
E
Y
Q
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
K83
D
K
E
P
P
K
F
K
Y
K
M
I
M
V
H
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
E67
L
M
E
R
F
G
T
E
Q
P
P
P
P
I
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
D108
G
E
S
S
L
S
G
D
Y
Y
M
P
T
L
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
0
N.A.
6.6
0
N.A.
6.6
100
0
100
93.3
6.6
53.3
6.6
6.6
P-Site Similarity:
100
100
N.A.
20
N.A.
13.3
0
N.A.
6.6
100
0
100
100
20
66.6
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
7
7
7
7
0
0
0
0
0
34
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
7
0
0
0
14
0
0
7
0
0
0
0
0
0
0
% D
% Glu:
0
7
47
0
0
0
0
7
0
7
14
34
14
0
34
% E
% Phe:
0
0
7
0
7
0
7
0
7
0
0
0
0
0
7
% F
% Gly:
40
40
0
0
0
7
7
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
34
7
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
7
7
0
0
0
7
40
0
0
7
0
7
14
% I
% Lys:
0
7
7
0
0
7
0
7
0
7
0
0
0
0
0
% K
% Leu:
7
7
0
7
7
0
14
7
0
7
40
0
0
14
7
% L
% Met:
0
7
0
0
0
0
0
0
0
0
14
0
7
0
0
% M
% Asn:
0
0
0
0
34
0
0
0
0
0
0
7
0
14
0
% N
% Pro:
0
0
0
14
7
47
47
0
7
7
14
14
7
0
0
% P
% Gln:
0
0
0
7
0
0
0
7
14
0
0
7
7
0
14
% Q
% Arg:
0
0
0
7
0
7
0
0
0
7
7
0
0
0
0
% R
% Ser:
7
14
7
7
7
14
0
34
7
0
0
0
0
0
7
% S
% Thr:
7
0
0
0
0
0
7
7
0
0
0
7
7
0
0
% T
% Val:
7
7
0
0
0
0
0
0
0
0
0
14
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
14
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
14
47
0
0
0
47
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _