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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
40.3
Human Site:
Y673
Identified Species:
63.33
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
Y673
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
Y673
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
Y673
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
Y710
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Rat
Rattus norvegicus
P11345
648
72910
S571
G
Y
A
S
P
D
L
S
R
L
Y
K
N
C
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
Y705
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Chicken
Gallus gallus
Q04982
806
89347
Y713
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Frog
Xenopus laevis
P09560
638
71941
L561
R
G
G
V
V
P
D
L
S
K
L
Y
K
N
C
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
Y683
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
Y684
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
Fruit Fly
Dros. melanogaster
P11346
782
88616
L688
L
F
M
V
G
R
G
L
L
R
P
D
M
S
Q
Honey Bee
Apis mellifera
XP_396892
715
80060
K632
K
L
R
S
D
T
P
K
A
L
K
R
L
T
E
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
Y702
L
F
M
V
G
R
G
Y
L
R
P
D
R
S
K
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
Y656
I
W
M
V
G
R
G
Y
L
Q
P
D
L
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
W717
S
A
A
G
T
P
E
W
M
A
P
E
V
L
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
100
100
6.6
100
100
66.6
6.6
80
86.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
100
100
13.3
100
100
86.6
20
86.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
0
0
0
0
0
7
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% C
% Asp:
0
0
0
0
7
7
7
0
0
0
0
74
0
0
0
% D
% Glu:
0
0
0
0
0
0
7
0
0
0
0
7
0
0
7
% E
% Phe:
0
67
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
7
7
7
74
0
74
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
60
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
7
0
0
0
0
0
0
7
0
7
7
7
7
0
67
% K
% Leu:
14
7
0
0
0
0
7
14
74
14
7
0
67
7
0
% L
% Met:
0
0
74
0
0
0
0
0
7
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% N
% Pro:
0
0
0
0
7
14
7
0
0
0
80
0
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% Q
% Arg:
7
0
7
0
0
74
0
0
7
14
0
7
7
0
7
% R
% Ser:
7
0
0
14
0
0
0
7
7
54
0
0
0
74
0
% S
% Thr:
0
0
0
0
7
7
0
0
0
0
0
0
0
7
0
% T
% Val:
0
0
0
80
7
0
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
67
0
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _