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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
23.94
Human Site:
Y82
Identified Species:
37.62
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
Y82
P
S
I
Y
L
E
A
Y
E
E
Y
T
S
K
L
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
Y82
P
S
I
Y
L
E
A
Y
E
E
Y
T
S
K
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
L59
L
Q
Q
R
E
Q
Q
L
L
E
S
L
G
N
G
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
N66
A
I
P
E
E
V
W
N
I
K
Q
M
I
K
L
Rat
Rattus norvegicus
P11345
648
72910
K9
E
H
I
Q
G
A
W
K
T
I
S
N
G
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
N62
P
L
S
C
R
V
W
N
I
K
Q
M
I
K
L
Chicken
Gallus gallus
Q04982
806
89347
Y82
P
S
I
Y
L
E
A
Y
E
E
Y
T
S
K
L
Frog
Xenopus laevis
P09560
638
71941
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
Y92
P
S
I
Y
L
E
A
Y
E
E
Y
T
S
K
L
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
Y88
P
T
I
Y
L
E
A
Y
E
E
Y
T
S
K
L
Fruit Fly
Dros. melanogaster
P11346
782
88616
Y99
L
W
F
L
P
T
E
Y
Q
E
L
T
S
K
L
Honey Bee
Apis mellifera
XP_396892
715
80060
Y66
P
S
I
Y
L
N
E
Y
Q
E
L
T
S
K
L
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
V89
F
K
Y
K
M
I
M
V
H
L
P
F
D
Q
H
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
I73
T
E
Q
P
P
P
P
I
F
L
E
E
Y
Q
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
L114
G
D
Y
Y
M
P
T
L
S
A
A
A
N
E
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
6.6
N.A.
13.3
6.6
N.A.
20
100
0
100
93.3
40
73.3
0
0
P-Site Similarity:
100
100
N.A.
13.3
N.A.
20
6.6
N.A.
26.6
100
0
100
100
46.6
80
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
7
34
0
0
7
7
7
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
7
% D
% Glu:
7
7
0
7
14
34
14
0
34
54
7
7
0
7
0
% E
% Phe:
7
0
7
0
0
0
0
0
7
0
0
7
0
7
0
% F
% Gly:
7
0
0
0
7
0
0
0
0
0
0
0
14
0
14
% G
% His:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
7
% H
% Ile:
0
7
47
0
0
7
0
7
14
7
0
0
14
0
7
% I
% Lys:
0
7
0
7
0
0
0
7
0
14
0
0
0
60
0
% K
% Leu:
14
7
0
7
40
0
0
14
7
14
14
7
0
0
60
% L
% Met:
0
0
0
0
14
0
7
0
0
0
0
14
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
14
0
0
0
7
7
7
0
% N
% Pro:
47
0
7
7
14
14
7
0
0
0
7
0
0
0
0
% P
% Gln:
0
7
14
7
0
7
7
0
14
0
14
0
0
14
0
% Q
% Arg:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
34
7
0
0
0
0
0
7
0
14
0
47
0
0
% S
% Thr:
7
7
0
0
0
7
7
0
7
0
0
47
0
0
0
% T
% Val:
0
0
0
0
0
14
0
7
0
0
0
0
0
0
0
% V
% Trp:
0
7
0
0
0
0
20
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
14
47
0
0
0
47
0
0
34
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _