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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ANPEP All Species: 11.21
Human Site: S132 Identified Species: 18.97
UniProt: P15144 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15144 NP_001141.2 967 109540 S132 K K L N Y T L S Q G H R V V L
Chimpanzee Pan troglodytes XP_523153 967 109577 S132 K K L N Y T L S Q G H R V V L
Rhesus Macaque Macaca mulatta XP_001093727 968 109887 S133 K K L N Y T L S Q G H R V V L
Dog Lupus familis XP_859826 931 105294 M125 T C K E S T S M I I I H S K K
Cat Felis silvestris
Mouse Mus musculus P97449 966 109633 K132 K K L N Y T L K G N H R V V L
Rat Rattus norvegicus P15684 965 109430 K132 K K L N Y T N K G N H R V A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514698 839 94749 Y33 I I A L S V V Y S Q E K N K N
Chicken Gallus gallus NP_990192 967 108652 G132 K L N Y T L Q G G F H A S L H
Frog Xenopus laevis NP_001088591 963 109575 N132 K L N H T K F N N F D A K L M
Zebra Danio Brachydanio rerio XP_001340256 965 110120 I132 I H S N K L T I K D S T T L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651674 999 115252 M156 E D C Y N I T M H A E E L N I
Honey Bee Apis mellifera XP_396261 982 112493 T145 M R I D E S F T N I K S Y S A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783617 1060 120846 N221 V I T L H I N N I T I R S N T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37898 856 97644 L51 N S V Q I N Y L E I D F H S A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 95.3 75.4 N.A. 76.3 77.8 N.A. 60.5 66.1 59 60.3 N.A. 35.6 37.2 N.A. 38.2
Protein Similarity: 100 99.4 97.9 85.1 N.A. 87.1 88.1 N.A. 70.4 78.8 74.2 74.9 N.A. 55.2 58.6 N.A. 57
P-Site Identity: 100 100 100 6.6 N.A. 80 66.6 N.A. 0 13.3 6.6 6.6 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 100 100 6.6 N.A. 80 66.6 N.A. 13.3 20 33.3 20 N.A. 20 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 0 8 0 15 0 8 15 % A
% Cys: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 8 0 0 0 0 0 8 15 0 0 0 0 % D
% Glu: 8 0 0 8 8 0 0 0 8 0 15 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 15 0 0 15 0 8 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 22 22 0 0 0 0 0 % G
% His: 0 8 0 8 8 0 0 0 8 0 43 8 8 0 8 % H
% Ile: 15 15 8 0 8 15 0 8 15 22 15 0 0 0 8 % I
% Lys: 50 36 8 0 8 8 0 15 8 0 8 8 8 15 15 % K
% Leu: 0 15 36 15 0 15 29 8 0 0 0 0 8 22 36 % L
% Met: 8 0 0 0 0 0 0 15 0 0 0 0 0 0 8 % M
% Asn: 8 0 15 43 8 8 15 15 15 15 0 0 8 15 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 8 0 0 8 0 22 8 0 0 0 0 0 % Q
% Arg: 0 8 0 0 0 0 0 0 0 0 0 43 0 0 0 % R
% Ser: 0 8 8 0 15 8 8 22 8 0 8 8 22 15 0 % S
% Thr: 8 0 8 0 15 43 15 8 0 8 0 8 8 0 8 % T
% Val: 8 0 8 0 0 8 8 0 0 0 0 0 36 29 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 15 36 0 8 8 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _