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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ANPEP
All Species:
14.55
Human Site:
S174
Identified Species:
24.62
UniProt:
P15144
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15144
NP_001141.2
967
109540
S174
K
G
S
L
V
K
D
S
Q
Y
E
M
D
S
E
Chimpanzee
Pan troglodytes
XP_523153
967
109577
S174
K
G
S
L
V
K
D
S
Q
Y
E
M
D
S
E
Rhesus Macaque
Macaca mulatta
XP_001093727
968
109887
S175
R
G
S
L
V
K
D
S
Q
Y
E
M
D
S
E
Dog
Lupus familis
XP_859826
931
105294
Y167
E
L
V
E
V
T
E
Y
L
V
V
H
L
R
E
Cat
Felis silvestris
Mouse
Mus musculus
P97449
966
109633
R174
Q
G
S
L
V
E
G
R
Q
Y
E
M
D
S
Q
Rat
Rattus norvegicus
P15684
965
109430
H174
Q
G
S
L
V
K
G
H
Q
Y
E
M
D
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514698
839
94749
Y75
P
K
L
P
W
N
Q
Y
R
L
P
K
S
L
I
Chicken
Gallus gallus
NP_990192
967
108652
H174
G
P
L
Q
Q
G
Q
H
Y
R
L
F
S
I
F
Frog
Xenopus laevis
NP_001088591
963
109575
S174
L
Q
A
G
K
E
Y
S
L
Y
T
E
F
I
G
Zebra Danio
Brachydanio rerio
XP_001340256
965
110120
S174
R
E
L
T
A
G
E
S
Y
E
L
Y
T
E
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651674
999
115252
F198
L
V
G
A
K
Q
F
F
V
I
E
L
Y
D
K
Honey Bee
Apis mellifera
XP_396261
982
112493
A187
L
D
T
L
R
K
G
A
Q
Y
I
V
N
L
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783617
1060
120846
T263
G
K
M
L
E
A
G
T
G
Y
V
L
E
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P37898
856
97644
A93
F
E
N
L
G
P
S
A
K
L
E
I
I
F
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.4
95.3
75.4
N.A.
76.3
77.8
N.A.
60.5
66.1
59
60.3
N.A.
35.6
37.2
N.A.
38.2
Protein Similarity:
100
99.4
97.9
85.1
N.A.
87.1
88.1
N.A.
70.4
78.8
74.2
74.9
N.A.
55.2
58.6
N.A.
57
P-Site Identity:
100
100
93.3
13.3
N.A.
66.6
80
N.A.
0
0
13.3
6.6
N.A.
6.6
26.6
N.A.
20
P-Site Similarity:
100
100
100
26.6
N.A.
86.6
86.6
N.A.
6.6
0
26.6
20
N.A.
26.6
60
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
8
0
15
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
22
0
0
0
0
0
36
8
0
% D
% Glu:
8
15
0
8
8
15
15
0
0
8
50
8
8
8
43
% E
% Phe:
8
0
0
0
0
0
8
8
0
0
0
8
8
8
15
% F
% Gly:
15
36
8
8
8
15
29
0
8
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
15
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
8
8
8
22
8
% I
% Lys:
15
15
0
0
15
36
0
0
8
0
0
8
0
0
15
% K
% Leu:
22
8
22
58
0
0
0
0
15
15
15
15
8
15
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
36
0
0
0
% M
% Asn:
0
0
8
0
0
8
0
0
0
0
0
0
8
0
0
% N
% Pro:
8
8
0
8
0
8
0
0
0
0
8
0
0
0
0
% P
% Gln:
15
8
0
8
8
8
15
0
43
0
0
0
0
0
8
% Q
% Arg:
15
0
0
0
8
0
0
8
8
8
0
0
0
8
0
% R
% Ser:
0
0
36
0
0
0
8
36
0
0
0
0
15
36
8
% S
% Thr:
0
0
8
8
0
8
0
8
0
0
8
0
8
0
0
% T
% Val:
0
8
8
0
43
0
0
0
8
8
15
8
0
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
15
15
58
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _