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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ANPEP
All Species:
9.09
Human Site:
S460
Identified Species:
15.38
UniProt:
P15144
Number Species:
13
Phosphosite Substitution
Charge Score:
0.46
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15144
NP_001141.2
967
109540
S460
H
P
L
S
T
P
A
S
E
I
N
T
P
A
Q
Chimpanzee
Pan troglodytes
XP_523153
967
109577
S460
H
P
L
S
T
P
S
S
E
I
N
T
P
A
Q
Rhesus Macaque
Macaca mulatta
XP_001093727
968
109887
S461
H
P
L
S
T
P
A
S
E
I
N
T
P
A
Q
Dog
Lupus familis
XP_859826
931
105294
L446
Y
S
K
G
A
S
V
L
R
M
L
S
S
F
L
Cat
Felis silvestris
Mouse
Mus musculus
P97449
966
109633
D459
H
P
L
S
S
P
A
D
E
I
K
T
P
D
Q
Rat
Rattus norvegicus
P15684
965
109430
N459
H
P
L
S
S
P
A
N
E
V
N
T
P
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514698
839
94749
E354
D
F
N
A
G
A
M
E
N
W
G
L
V
T
Y
Chicken
Gallus gallus
NP_990192
967
108652
D458
H
P
L
T
F
R
E
D
E
I
N
T
P
A
Q
Frog
Xenopus laevis
NP_001088591
963
109575
E455
H
P
L
T
S
K
E
E
E
V
N
S
P
S
E
Zebra Danio
Brachydanio rerio
XP_001340256
965
110120
E459
H
P
L
S
S
K
E
E
D
V
Q
R
P
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651674
999
115252
F488
H
K
I
S
H
E
V
F
N
P
Q
E
I
S
E
Honey Bee
Apis mellifera
XP_396261
982
112493
E468
H
Q
I
S
V
K
V
E
H
P
D
E
I
S
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783617
1060
120846
N545
H
P
V
R
V
P
V
N
S
P
D
E
I
N
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P37898
856
97644
N372
H
P
I
E
V
P
V
N
N
A
D
E
I
N
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.4
95.3
75.4
N.A.
76.3
77.8
N.A.
60.5
66.1
59
60.3
N.A.
35.6
37.2
N.A.
38.2
Protein Similarity:
100
99.4
97.9
85.1
N.A.
87.1
88.1
N.A.
70.4
78.8
74.2
74.9
N.A.
55.2
58.6
N.A.
57
P-Site Identity:
100
93.3
100
0
N.A.
73.3
80
N.A.
0
66.6
40
40
N.A.
13.3
13.3
N.A.
20
P-Site Similarity:
100
100
100
20
N.A.
80
100
N.A.
6.6
73.3
80
60
N.A.
33.3
40
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
8
29
0
0
8
0
0
0
36
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
15
8
0
22
0
0
8
0
% D
% Glu:
0
0
0
8
0
8
22
29
50
0
0
29
0
8
29
% E
% Phe:
0
8
0
0
8
0
0
8
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
8
8
0
0
0
0
0
8
0
0
0
0
% G
% His:
86
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
22
0
0
0
0
0
0
36
0
0
29
0
0
% I
% Lys:
0
8
8
0
0
22
0
0
0
0
8
0
0
0
0
% K
% Leu:
0
0
58
0
0
0
0
8
0
0
8
8
0
0
8
% L
% Met:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
22
22
0
43
0
0
15
0
% N
% Pro:
0
72
0
0
0
50
0
0
0
22
0
0
58
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
15
0
0
0
58
% Q
% Arg:
0
0
0
8
0
8
0
0
8
0
0
8
0
0
0
% R
% Ser:
0
8
0
58
29
8
8
22
8
0
0
15
8
22
0
% S
% Thr:
0
0
0
15
22
0
0
0
0
0
0
43
0
8
0
% T
% Val:
0
0
8
0
22
0
36
0
0
22
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _