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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ANPEP All Species: 18.48
Human Site: S84 Identified Species: 31.28
UniProt: P15144 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15144 NP_001141.2 967 109540 S84 P N T L K P D S Y R V T L R P
Chimpanzee Pan troglodytes XP_523153 967 109577 S84 P N T L K P D S Y Q V T L R P
Rhesus Macaque Macaca mulatta XP_001093727 968 109887 S85 P N T L K P D S Y Q V T L R P
Dog Lupus familis XP_859826 931 105294 W77 T L A Q S K P W N H Y R L P K
Cat Felis silvestris
Mouse Mus musculus P97449 966 109633 S84 P K T L I P D S Y R V I L R P
Rat Rattus norvegicus P15684 965 109430 S84 P K T L I P D S Y Q V T L R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514698 839 94749
Chicken Gallus gallus NP_990192 967 108652 Y84 T A L K P E S Y E V T L Q P F
Frog Xenopus laevis NP_001088591 963 109575 Y84 T T L K P I H Y D V E L Q P Y
Zebra Danio Brachydanio rerio XP_001340256 965 110120 S84 W R L P Q T L S P E T Y K V N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651674 999 115252 Y108 G H D D T P K Y D R D V R L P
Honey Bee Apis mellifera XP_396261 982 112493 V97 L P R S I V P V S Y E L R L V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783617 1060 120846 N173 P R D V I P E N Y Q L Y L K P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37898 856 97644
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 95.3 75.4 N.A. 76.3 77.8 N.A. 60.5 66.1 59 60.3 N.A. 35.6 37.2 N.A. 38.2
Protein Similarity: 100 99.4 97.9 85.1 N.A. 87.1 88.1 N.A. 70.4 78.8 74.2 74.9 N.A. 55.2 58.6 N.A. 57
P-Site Identity: 100 93.3 93.3 6.6 N.A. 80 80 N.A. 0 0 0 6.6 N.A. 20 0 N.A. 33.3
P-Site Similarity: 100 100 100 6.6 N.A. 80 86.6 N.A. 0 0 0 13.3 N.A. 26.6 0 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 15 8 0 0 36 0 15 0 8 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 8 0 8 8 15 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 8 0 0 8 0 0 0 0 0 % H
% Ile: 0 0 0 0 29 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 15 0 15 22 8 8 0 0 0 0 0 8 8 8 % K
% Leu: 8 8 22 36 0 0 8 0 0 0 8 22 50 15 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 22 0 0 0 0 0 8 8 0 0 0 0 0 8 % N
% Pro: 43 8 0 8 15 50 15 0 8 0 0 0 0 22 50 % P
% Gln: 0 0 0 8 8 0 0 0 0 29 0 0 15 0 0 % Q
% Arg: 0 15 8 0 0 0 0 0 0 22 0 8 15 36 0 % R
% Ser: 0 0 0 8 8 0 8 43 8 0 0 0 0 0 0 % S
% Thr: 22 8 36 0 8 8 0 0 0 0 15 29 0 0 0 % T
% Val: 0 0 0 8 0 8 0 8 0 15 36 8 0 8 8 % V
% Trp: 8 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 22 43 8 8 15 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _