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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ANPEP All Species: 18.18
Human Site: Y289 Identified Species: 30.77
UniProt: P15144 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15144 NP_001141.2 967 109540 Y289 F I V S E F D Y V E K Q A S N
Chimpanzee Pan troglodytes XP_523153 967 109577 Y289 F I V S E F D Y V E K Q A S N
Rhesus Macaque Macaca mulatta XP_001093727 968 109887 Y290 F I V S E F T Y V E K R A S N
Dog Lupus familis XP_859826 931 105294 R281 G H G N Y A L R V T G P I L D
Cat Felis silvestris
Mouse Mus musculus P97449 966 109633 N288 Y I V S E F K N I S S V S A N
Rat Rattus norvegicus P15684 965 109430 Y288 Y I V S E F K Y V E A V S P N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514698 839 94749 A189 T T F V G E L A D D L A G F Y
Chicken Gallus gallus NP_990192 967 108652 Y288 F I V S Q F D Y V E N N T G K
Frog Xenopus laevis NP_001088591 963 109575 D289 S I G N D G N D T V T G V K I
Zebra Danio Brachydanio rerio XP_001340256 965 110120 T288 A F I V S E F T Y I E Q K L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651674 999 115252 Y317 M S T Y L V A Y A I S D F T H
Honey Bee Apis mellifera XP_396261 982 112493 M302 F I V S D F E M L K S E S G K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783617 1060 120846 E378 V G Y F D K T E M Y T E N G V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37898 856 97644 S207 A D L R Y V E S N N F R I P V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 95.3 75.4 N.A. 76.3 77.8 N.A. 60.5 66.1 59 60.3 N.A. 35.6 37.2 N.A. 38.2
Protein Similarity: 100 99.4 97.9 85.1 N.A. 87.1 88.1 N.A. 70.4 78.8 74.2 74.9 N.A. 55.2 58.6 N.A. 57
P-Site Identity: 100 100 86.6 6.6 N.A. 40 60 N.A. 0 60 6.6 6.6 N.A. 6.6 33.3 N.A. 0
P-Site Similarity: 100 100 93.3 20 N.A. 66.6 73.3 N.A. 6.6 66.6 26.6 26.6 N.A. 20 73.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 0 0 0 0 8 8 8 8 0 8 8 22 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 22 0 22 8 8 8 0 8 0 0 15 % D
% Glu: 0 0 0 0 36 15 15 8 0 36 8 15 0 0 0 % E
% Phe: 36 8 8 8 0 50 8 0 0 0 8 0 8 8 0 % F
% Gly: 8 8 15 0 8 8 0 0 0 0 8 8 8 22 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 58 8 0 0 0 0 0 8 15 0 0 15 0 8 % I
% Lys: 0 0 0 0 0 8 15 0 0 8 22 0 8 8 15 % K
% Leu: 0 0 8 0 8 0 15 0 8 0 8 0 0 15 0 % L
% Met: 8 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 15 0 0 8 8 8 8 8 8 8 0 36 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 8 0 15 0 % P
% Gln: 0 0 0 0 8 0 0 0 0 0 0 22 0 0 0 % Q
% Arg: 0 0 0 8 0 0 0 8 0 0 0 15 0 0 0 % R
% Ser: 8 8 0 50 8 0 0 8 0 8 22 0 22 22 0 % S
% Thr: 8 8 8 0 0 0 15 8 8 8 15 0 8 8 0 % T
% Val: 8 0 50 15 0 15 0 0 43 8 0 15 8 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 15 0 8 8 15 0 0 43 8 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _